Fluticasone

Chemical name

(6альфа,11бета,16альфа,17��льфа)-6,9-Дифтор-11,17-диг идрокси-16-метил-3-оксо��ндроста-1,4-диен-17-карб отионовой acid S - (ftormetilovy) ether

Gross

C22-H27-F3-O4-S

Characteristics

White or no white powder, practically insoluble in water, dissolves easily in demetilsulfoxide and dimethylformamide, and slightly soluble in methanol and 95% ethanol.

Of drugs

Drugs, the anti-inflammatory, protiwallergicescoe, protivozudnoe. Ingibiruet proliferatiou fat cells Eosinophils, lymphocytes, macrophages and Klebsiella reduces products and liberatiou mediators of inflammation and other biologically active substances (gistamina, eikozanoidov, lakotrienov and Cytokines). Using inhalations for 10-20% dose sorbed in the lungs, and the rest of the proglatavetsa and liver produces inactive metabolite. Liver secretiruet jelchew with 87-100% rate, which hit intestine (see intestinal). The on / in the application T_1/2 not more than 3 hours

Indications

Nazalny spray-allergic rinita; Asthma prevention of exacerbations of asthma; Cream and ointment, eczema, host pocesuha (GUM), psoriasis, neirodermatozy (including simple zoster), the red flat zoster, the reactions contact gipercuvstvenosti, diskoidnaya red erythematosus, generalized eritrodermia, insect bites, red potnica, seborainey dermatitis.

Contraindications

All forms : hypersensitivity, pregnancy, breast-feeding (at the time of treatment is halted); Ointment and cream : acne (pink, ordinary), perioralny dermatitis, perianalny and genital itching, the primary skin bacterial, viral and fungal etiology, chest age (up to 1 year); Spray and aerosol :'s age (up to 4 years).

Side-Effects

Nazalny spray-chair irritation, unpleasant taste and smell, perforation nose; Spray for inhalations - candidiasis nasal cavity, ohriplosti vote, the paradoxical bronchospasm; Cream and ointment-burning and itching at the site of, nurturing, gipopigmentation, gipertrihoz, allergic contact dermatitis; In the long-term use-gipercortitizm symptomatic.

Precautions

Be wary appointed after systemic application of glucocorticoids, especially if there is a violation of the napochechnikov, for aerosol inhalations, with the tuberculosis lungs. Nazalny spray recommended at regular intervals; Treatment for aerosol inhalations should not terminate abruptly before the desirable ingalirovti agonist бета_2-адренорецептор��в short-acting, and after-mouth rinse. There is a need to avoid falling creams or ointments in the eye before applying the new skin removed carefully cultivated.

Dosing and Administration

Nazalny spray-on the morning of 100 µ g (children under the age of 12-50 µ g) in each nostril; Spray for inhalations, with bronchial asthma light, moderate and severe two times a day by 100-250 µ g, 250-500 µ g and 500 g, respectively (children and adolescents up to 16 years in the 50-100 µ g); ointment and cream are thin in plot stung the skin twice a day.

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