Mazipredone

Chemical name

21-Дезокси-21-N-(N'-метилп��перазинил)преднизоло на hydrochloride

Gross

C26-h38-n2-o4h2hcl

Characteristics

Powder white. Rat in the water.

Of drugs

Drugs, the anti-inflammatory, protiwallergicescoe, immunodepressivne, protivosokowoe, protivooterne, protivozudnoe. Interacts with specific receptors zitoplazmaticakimi, ingibiruet fosfolipazu A_2 reduces synthesis lakotrienov and NG. The local application of big vessels skin reduces the permeability of capillaries, stabilizes proliferatiou epidermalnah cells and fibroblasts, oppressing cell chemotaxis моноцитарно-макрофаг��льной system reduces the number bazofilov violates degranulatia fat cells. Is inwalucia limfoidna tissue products reduces antibodies. It stimulates the heart functions, restores sensitivity adrenergicakih receptors to kateholaminam increases vazopressornye influence behind sodium and Vodu.vsasavetsa through the skin (to a system of the organism) and the digestive tract.

Indications

Anaphylacticskie reactions, severe asthma, various types of shock, a severe lack napochechnikovaya, intoxication with infectious diseases, hepatic coma, severe laringotraheobronhit children, diffuse disease connective tissue, systemic vasculita, glomerulonefrita, autoimmunny hepatitis, severe form of the disease and ulcerative nonspecific ulcerative colitis acquired immune deficiency gemoliticaskie, gemoblastozy, eczema, external otitis, dermatitis (Contact, allergic, oprelosti) neirodermit, red flat zoster, diskoidnaya red erythematosus, psoriaticescoe defeated skin gnezdnaya alopecia.

Restrictions on the use of

Acute infectious diseases, tuberculosis, decompensirovanny cirrhosis with the syndrome gantries hypertension, severe arterial hypertension, heart failure, terminal kidney failure with renal syndrome osteodystrophies.

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

To use the system, saying the disease stomach or duodenal ulcer in the phase of deterioration, the syndrome Itsenko - Kushinga, diabetes under decompensation expressed osteoporosis, personality disorders, pregnancy, breast-feeding; Bacterial (including sifiliticalkie, tuberculosis), viral, fungal skin infections, tumors or pre skin; after birth (because of the availability of benzyl alcohol).

Side-Effects

Arterial hypertension, vasculit, steroidnyi diabetes, glukozuria, steroidnaya cataracts, miopatia, erosivno-azwenne shock syndrome, sleep disturbance, psychosis, obesity, bone cortex napochechnikov, reducing muscle mass whose fluid, osteoporosis, lower resistance to infections, menstrual disorders cycle syndrome "lifting", leucocytosis, gipokaliemia, gipocalziemia, nitrogenous negative balance, the slowdown in healing tissue, skin itching, rash, dryness and atrophy of the skin, dermatitis perianalny, gipopigmentation, gipertrihoz, ekhimozy.

Patient interaction

Ters protivodiabeticakih effect of increasing anti-, cardiac glycosides (including toxicity), ulzerogennosti NPVS risk gipokaliemii in treating amfoteritinom B slabitionami, dioretikami. Etakrinova acid increases the likelihood of bleeding in the digestive tract, induktora mikrosomalnogo oxidation (phenobarbital, difengidramin, phenytoin, rifampicin, etc.) negate glukokortikoidnuu activity, some antimalarial drugs, estrogena, metandrostenolon-make it last, moreover, reduces the severity of certain complications (osteoporosis, nitrogenous negative balance).

Precautions

Principal dose inside should be appointed in the morning. Termination treatment should gradually begin reducing the dose taken in the evening and daytime hours. Required regular monitoring AD cells of peripheral blood, blood glucose and electrolytes content. Older and weakened patients in long-term care shown by the additional anabolic steroids. Multiple local function (or use large parts of the skin) requires periodic determination of cortisol plasma. Avoid contact ointments in the eye. Be wary Local applied in the progressive stage of psoriasis.

Dosing and Administration

Inside, in / in, naruzhno. The normal daily intake for admission into the 20-mg, the maximum 100 mg supporting-5-15 mg. In urgentnykh situations (shock asthma status, etc.), in / in struino slowly or drip, adults-30-90 mg (upgradeable doses up to 200 mg and above), children 1-3 mg / kg When an external application, not on the skin, thin layer of 2-3 times a day; After the disappearance of clinical symptoms gradually reduce the number smazawanyi : at the outset, once a day, and then one day, two days, etc.; from visual ackzematosnom otite before the materials needed toilet audible passage vazelinovm oil and oxidative 0,25-2% solution of silver nitrate; treating psoriasis recommends that you use, but a child cream and under occluzionnuyu cast.

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