Prednicarbate

Chemical name

(11бета)-17-[(Этоксикарбо нил)окси]-11-гидрокси-21- (1-оксопропокси)прегна -1,4-диен-3,20-дион

Gross

C27-H36-O8

Of drugs

Drugs, the anti-inflammatory, antiekssoudativoe, protiwallergicescoe, desencibilizirutee, protivozudnoe, sossoudossouerveshchee. Local противовоспалительны й effect is stimulation lipokortina synthesis, inhibiting fosfolipazu A_2, stifles education in the arahidonova acid and the release of inflammation mediators-NG factor activate platelets and lakotrienov. 4-3 membranes, including organell cell; way down enzymes, cell damage and degranulatia fat cells; reduces blood migration and capillary permeability, improves. Can skin through intaktnuu skin; Inflammation and / or other skin diseases increase the absorption through skin. Improves the surface of the skin manifestations eritema, seals, itching and flaking, reduces the severity of symptoms by 37% in minutes and by 76% in atopicescom Acne.

Indications

Skin diseases, causing inflammation and everything, including ackzemu (acute, chronic, atopical) neirodermit, psoriasis; I burns degrees.

Contraindications

Hypersensitivity, skin reactions vaccinations, fungal, bacterial and viral infections of the skin, including skin symptoms for tuberculosis, AIDS, wind smallpox, mikozah; Perioralny dermatitis, pregnancy, breast-feeding (at the time of treatment is halted), Children and Youth age (up to 18 years).

Side-Effects

Local reactions, skin atrophy, swelling, redness, irritation symptoms (itching, parestesia, ladies), pustulezne skin, allergic contact dermatitis (skin rashes, urticaria), dry skin, gnanichkove miliarnae skin, tinea, gipopigmentation, perioralny dermatitis, scars, teleangioektasia secondary infections; Children, the oppression napochechnikov crust, гипоталамо-гипофизар��о-надпочечниковая malnutrition (stunting, changing body mass index, low levels of cortisol in the blood plasma, etc.) syndrome Itsenko - Kushinga, raising vnutricerepnogo pressure (headache, bilateral edema and inflammation of the nipple nerve membranes, thus rodnicka, etc.).

Precautions

Avoid contact with eyes, and the imposition of the infested area casts. Where a treatment period of the new skin changes, or in the case of side effects should see a doctor. Symptoms гипоталамо-гипофизар��о-надпочечниковой Failure in the need to continue treatment require dose reduction or designate another, less active glukokortikoida. The lifting of preparation of the symptoms of local irritation. If there is or there during therapy skin infections needed antibacterial or antifungal means; If a mother does not kupiruyutza, prednicarbat overturned. For patients with an infected surface or in the case of imposing casts required periodic monitoring of hormone status, including determination of the level of cortisol in plasma and urine. It should not be combined with glukokortikoidami rezorbtivogo actions (more likely systemic side effects).

Dosing and Administration

Locally. Mark thin in the infection looks easy vtiraya, 1-2 times a day; Course 2-3 (no more than 4) weeks.

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