Prednisone

Chemical name

17,21-Дигидроксипрегна-1 ,4-диен-3,11,20-трион

Gross

C21-H26-O5

Of drugs

Drugs, the anti-inflammatory, противоаллергическое . 4-3 cell membranes, including lizosomaiona reduces withdrawal proteolytic enzymes from lizosom (Braking phase alteration and limitation home inflammation), ingibiruet fosfolipazu A_2 violates liberatiou arahidonova acid and the resulting synthesis of oppressing NG auxikislot and lakotrienov hampered gialuronidasy activity and reduces the capillary permeability (oppression ekssoudace phase), the activity of fibroblasts (oppression phase proliferation). Antiallergic properties due to the violation of degranulation fat cells decrease lakotrienov synthesis and suppression of antibodies, protivosokove-delayed sodium and water, increasing pressure response to endo- and sossoudossoujiwate exogenous substances and incentive effects on the heart functions, toxological-up inactivating toxic substances in the liver, lower permeability of cell membranes. If ingestion is readily absorbed, C_max in plasma observed in 1-2 hours Material exceeds 90%. Treated biotransformation mainly in the liver is mainly kidneys. As the dose increased T_1/2 total Cl, the distribution and the degree of bonding with the squirrels. Affects carbohydrate, protein, fat and vodno-soleva exchange. Increases the level of glucose in the blood, to the accumulation of glycogen in the liver and strengthens glukoneogenez. Activates the katabolizma slows regeneration, oversees dezaminirovanie amino acids in the liver contributes to the redistribution of adipose tissue back in the body of sodium and water, increases withdrawal potassium; Stimulates the cardiovascular system, improves the tone and arteriol Oxytocics the heart increases and the impact of minutes, bring forth, the antitoksicski and immunodepressive effect increases secreting mucous membrane of stomach acidity and gastric juice.

Indications

Arthritis, rheumatoid arthritis, dermatomiozit, nodular periarteriit, sklerodermia, spinal disease, bronchial asthma, allergic disease, Addison disease, the acute lack of crust napochechnikov, adrenoguenitalny syndrome, hepatitis, hepatic coma, gipoglikemicakie state lipoidnyi argued, agranulozitos, various forms of leukaemia, chlamydia, trombozitopenica purpura, haemolytic anaemia, infectious mononucleosis, acute pancreatitis, vesicular disease, eczema, skin, exfoliativei dermatitis, psoriasis, pocesuha, seborainey dermatitis, red erythematosus, eritrodermia, alopecia; prevention and treatment of shock.

Restrictions on the use of

Diabetes mellitus, nonspecific infection, latent tuberculosis, pregnancy (especially I trimester).

Contraindications

Ulcers disease stomach and duodenal ulcers in the phase of deterioration, osteoporosis, a disease Itsenko - Kushinga, the propensity to pulmonary, renal failure, severe arterial hypertension, systemic mikozy, viral infection, vaccination period, the active form of tuberculosis, productive and symptoms of mental illnesses, increased sensitivity to resistance.

Side-Effects

Reduced resistance to infection, giperglikemia up to the development of steroid diabetes, a negative balance of nitrogenous, osteoporosis, aseptic necrosis of the bones, increased acidity gastric juice ulzerogennoe effect on the stomach, gipokaliemia whose sodium and water, oedema, arterial hypertension, the blood coagulability syndrome Itsenko - Kushinga, increased body mass index, "lunoobraznoe" a person steroidnaya cataracts, glaucoma latentnaya, the menstrual cycle in women, insomnia, muscle weakness; the syndrome associated with the oppression or muscle napochechnikov crust.

Patient interaction

Makes eliminatiu barbiturates, digitoksina, penicillin, levomicetina. Phenobarbital, difenin, dimedrol, ephedrine increase speed biotransformation. Gipokaliemii The risk increases when combined with amfoteritinom and cardiac glycosides. NPVS increase (each) ulzerogennosti. In combination with acetylsalicylic acid may gipoprotrombinemii development.

Dosing and Administration

Inside. Adult initial dose : 20-30 mg / day supporting dose-5-10 mg per day. If necessary, the initial dose may be up to 15-100 mg / day supporting-15 mg per day. Daily dose should be reduced gradually. For children initial dose of 1-2 mg / kg body weight per day in 4-6 receptions supporting-480 µ g / kg / day. The highest single dose for adults is 15 mg daily, 100 mg. In a system of the large dosage for a short time.

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