Triamcinolone

Chemical name

(11бета,16альфа)-9-Фтор-11, 16,17,21-тетрадигидрокси��регна-1,4-диен-3,20-дион

Gross

C21-H27-F-O6

Characteristics

White or white with a yellow-brown crystalline powder. Nerastvorim water, poorly soluble in alcohol.

Of drugs

Drugs, the anti-inflammatory, protiwallergicescoe, immunodepressivne, glukokortikoidne. Activates specific receptors located in zitoplazme Organs cells, induces the synthesis and Mrnk special education class protein-lipokortinov-one lipomodulin, oppressing activity fosfolipaza A_2. Besides all kinds of exchange, the antianaboliceski and kataboliceski effects. Decreases glucose disposal insulinzawisimami tissues is giperglikemia, increase glycogen in the liver (activates glukoneogenez), increases the disintegration of fats, delaying sodium ions and water, contributes to the development of potassium ions reduces the absorption of calcium ions, induces secretion paratgormona mobilization calcium from the bone. Противовоспалительны е properties due to the stabilization of cell membranes, including fat, and organell (lizosom) oppression activity fosfolipaza A_2 (lipomodulin), the termination of liberation arahidonova acid from phospholipids of cell membranes, and a decline in the standard of its metabolism (GHG Тх, lakotrienov). Ingibiruet gialuronidazu hinders split base material connective tissue, slowing division fat cells and reduces their degranulatia (releases gistamina, serotonin, bradikinina), suppresses the synthesis factor activated platelets and proliferatiou connective tissue. Reduces the number of air and B-limfozitov violates interacting stops migration B-limfozitov (immunodepressivne protiwallergicescoe and in the future). Decreases concentration of immunoglobulins in the serum, oppressing cooperation phagocytes and lymphocytes. Protivosokowoe and antitoxic effect is associated with an increase in AD (for the increase in the concentration of circulating catecholamines and the restoration of sensitivity to adrenoretseptorov and vazokonstriktion), a decrease vascular permeability wall мембранопротективным и properties activated liver enzymes involved in the metabolism endo- and xenobiotics. Increases nervous anxiety, reduces the number of CD4 and Eosinophils increases-cells (stimulates a эритропоэтинов). After intake of rats 20-30%. The plasma 40% is associated with malnutrition. T_1/2 (tabletirovannaya form) is 5 pm Treated biotransformation in the liver with the formation of active metabolites. T_1/2 in tissues, 18-36 hrs Excreted primarily in the kidneys inactive Forme.posle oral the maximum effect seen in 1-2 h in / m after 48 hours The action depends on the way to 2.5 days (oral), 1-6 weeks (in m), or a few weeks (in the joint cavity).

Indications

Надпочечниковая deficiency, аутоиммунный тиреоидит, гиперкальциемия in malignant tumors, псориатический arthritis, gouty and rheumatoid arthritis (including ювенильный) ancylosing спондилит, bursitis, тендовагинит, traumatic arthritis, эпикондилит, systemic lupus red, ревмокардит, пемфигус, syndrome Stevens-Johnson (мультиформная erythema), dermatitis (эксфолиативный, герпетиформный, буллезный, себорейный contact, flaccid), psoriasis, allergic rhinitis, bronchial asthma, savorotocnaya or plant disease, allergic conjunctivitis, keratit, iridotsyklit, sarkoidoz, Leffler syndrome, Lyme, aspirate pneumonia, idiopathic purpura trombozitopenica adult secondary education thrombocytopenia, anemia (Autoimmune Hemolytic, genetic gipoplastical) eritroblastopenia acute or chronic lymphoblastic leukaemia, chlamydia, fell lymphoma, breast cancer, prostate cancer cancer, mielomnaya disease tuberculosis meningitis, acute lymphoblastic for children argued syndrome, Baby Ulcerative Colitis, ulcerative disease, gluten, hyperthermia with malignant tumors.

Contraindications

Hypersensitivity, systemic mikozy, glaucoma, a disease hospital of stomach and duodenal ulcers, disruption of the kidneys, osteoporosis, acute viral and bacterial infections, pregnancy, breast-feeding (at the end of treatment), children up to six years.

Side-Effects

Insomnia, anxiety, withdrawal syndrome (napochechnikovaya deficiency), a secondary immune (exacerbation of chronic infectious diseases, infectious generalization process, the development of opportunistic infections), slowing sh processes steroidnyi diabetes, syndrome Itsenko - Kushinga, arterial hypertension, liver diseases, heart arrhythmia, swelling, muscle weakness, muscle atrophy, osteoporosis, multiple caries, spontaneous fractures, stunted growth of children, societies ulcer stomach, intestines atony, the propensity to tromboobrazovaniu, atrophy of skin on the ground applications, gipertrihoz, nurturing, folliculitis, mazeration or dry skin, allergic reactions.

Patient interaction

Reduces effective oral gipoglikemicakih of insulin, and gipotenziveh mochegonnah preparations somatotropina. In combination with viral vaccines to replicating viral particles, and / or low levels of antibodies. Do side effects NPVS, drugs and immunosuppressants.

Overdosing

Symptoms : syndrome Itsenko - Kushinga, giperglikemia, glukozuria, skin irritation at the application site, itching, Jjenie.lechenie : maintaining vital functions (in the face of the gradual elimination of the drug).

Dosing and Administration

Inside the food. Adults and adolescents (over 12 years) with inadequate crust napochechnikov - 4-12 mg / day one (morning), or 2 admission (morning and afternoon). In other states : 4-48 mg / day one or two reception. B / m 40-80 mg, if necessary, again in four weeks. The joint cavity or vagina tendon-2.5-15 mg repetitive injections as needed. Children from 6 to 12 years, with the lack of crust napochechnikov : 0.117 mg / kg single morning or 2 admission, in other cases, 0,416-1,7 mg / kg; Maximum daily intake for children weighing up to 25 kg to 14 mg. B / m-40 mg repetitive injections within 4 weeks, as appropriate, or 0,03-0,2 mg / kg (repeated at 1-7 days).

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