Urbazon

Roman name

Urbason #

The composition and the form of

1 USD or 1 bottle dry material for the preparation of injection solution contains metilprednizolona (in the form of gidrogensuktinata sodium salt) 250, or 1000 mg, respectively; together with the solvent (water for injection), in sealed to 5 and 10 ml, in a package 1 and 5, or 21.90, respectively.

Of drugs

Disinfecting, protiwallergicescoe, immunodepressivne. Meets either an absolute or relative deficiency of endogenous glucocorticoids.

Farmakodinamika

4-3 cell membranes, reduces the capillary permeability, improves. Increases the level of glucose in the blood, stimulates catabolised violates the mineralization of bone tissue; Immunodepressiu is (linked to the break up of Cytokines - interleikina 1.2 gamma-interferon from lymphocytes and macrophages).

Indications

Shock (anaphylactic, Burns trauma, cardiogenny), brain swelling, shock lung and asthma status Addisonov kriz, Watenausa-friedriksena syndrome, the crisis immunological incompatibility with organ transplantation.

Pregnancy and lactation

Acceptable, but only on strict conditions (breast-feeding should be suspended).

Contraindications

Гиперчувствительност ь. For long-term use, not for health reasons : stomach ulcers and duodenal ulcers, severe osteoporosis; Mental disorders (including in history), a simple herpes, herpes zoster (viremical shape), chickenpox, a period of 8 weeks and up to 2 weeks after vaccination, amebiaz, systemic mikozy, poliomyelitis (with the exception of бульбарно-энцефаличе��ких Forms), lymphomas, developing after BCG vaccination, glaucoma.

Side-Effects

With long-term use, lunoobraznoe person obesity, muscle weakness, hypertension, osteoporosis, reduced tolerance to glukoze, diabetes mellitus, the sexual secretions of hormones (amenorea, girsutizm, impotence); Revolution, petehii, ekhimozy, societies face, oedema, the delay sodium in the body, increased withdrawal potassium atrophy crust napochechnikov, vasculit, unpleasant feelings in epigastria, defeat ulcerated stomach or duodenal ulcer, increased risk of infectious diseases, the immune processes slow healing, a slowdown in the growth of children asepticalkie bone necrosis (head femur and humerus), glaucoma, cataracts, mental disorders, increased risk of atherosclerosis, pancreatitis.

Patient interaction

Do toxicity cardiac glycosides; Gipoglikemicescuu reduces activity protivodiabeticakih funds antikoagulyantnuu derived from solid increases down saluretikami potassium and the risks of gastrointestinal bleeding in the face противовоспалительны х products. Effect reduce barbiturates, rifampicin and phenytoin.

Precautions

In heavy infections necessarily combination with antimicrobial therapy. For very strict conditions designate children.

Dosing and Administration

In / in slowly. Adults - 250-1000 mg one or more times a day; Children, ranging from 4 to 20 mg / kg body weight. The interval between wvedeniami from 30 minutes to 24 hours In light shock, cardiogennom shocked, oteke brain astmaticescom status, in the early stages of hypovolemic shock, and 30 mg / kg body weight. The contents of sealed dissolving 5 (250 mg), or 10 (1000 mg) ml of water for injection.

Directory → Hormones and their antagonists → Adrenal → Glukokortikoida → Urbazon