Desoxycortone

Chemical name

21-Гидроксипрегн-4-ен-3,2 0-дион (as acetate or enanthate)

Gross

C21-H30-O3

Characteristics

White or with a weak Navy blue crystalline powder odourless. Virtually nerastvorim in water, soluble in alcohol and oils.

Of drugs

The drugs - минералокортикоидное . Changes membrane permeability izvitah channel for ions, delaying sodium and water, contributes to the development of potassium. Inaguiruetsa in the liver. Excreted with jelchew and urine. Increases hydrophily tissues, BCC, AD. Do tone and improves efficiency poperechnopolostah muscles.

Indications

Addison disease, a temporary decline in the crust napochechnikov (gipokortitizm), male, man, adinamia, gipohloremia.

Contraindications

Arterial hypertension, severe heart failure with otecnam syndrome, arteriosclerosis, stenocardia, jade, principally, cirrhosis.

Side-Effects

Peripheric oedema, arterial hypertension, heart failure, allergic reactions.

Patient interaction

Effect increase adrenomimetiki, weaken and increase the risk of developing gipokaliemii - dioretiki. Compatible with glukokortikoidami and sodium chloride (with Addison disease).

Precautions

Treatment must be carried out under the close supervision of assistant at the high risk of side effects; Needs regular determination of the level of electrolytes in the blood serum. To avoid development gipokaliemii patients must use food rich in potassium (fruits, vegetables).

Dosing and Administration

V / m; At the time of Addison, depending on the severity of the disease, type of 5 mg three times a week and 10 mg (highest single dose) daily prior to the reduction of symptoms and diseases, and then to 5 mg 1-2 times a week; in acute malnutrition crust napochechnikov and addisonicescom krize for 5-10 mg four times daily (the highest daily dose of 25 mg); addisonizme to appoint 5 mg a day (15-20 at the injection treatment), gipotonicakih with conditions in the face of gipofunktion crust napochechnikov-to 5 mg a day or two days (total 12-15 �нъекций).Сублингваль��о (pills custody tongue or cheek until resorption not liquid) for 2.5-5 mg daily or every other day.

Directory → Hormones and their antagonists → Adrenal → Mineralokortikoida → Desoxycortone