Fludrocortisone

Chemical name

(11бета)-9-Фтор-11,17,21-три��идроксипрегн-4-ен-3,20-д ион (and in the form of 21-azetta)

Gross

C21-H29-F-O5

Of drugs

The drugs-mineralokortikoidne, glukokortikoidne. Increases AD reabsorbqiyu sodium, water, and the secretion of potassium in renal bone. Imagine a ACTG function napochechnikov, stimulates glukoneogenez, the breakdown of proteins (a nitrogenous negative balance), is immunodepressivnuu and противовоспалительну ю activity; in the local application reduces itching and exudation. Well drawn from the blood. Easily passes gistogematicalkie barriers. T_1/2 - 18-36 h. Return with urine in the form of metabolites. The small portion excreted lactoirutmi dairy disorders.

Indications

Primary and secondary napochechnikovaya deficiency, adrenoguenitalny syndrome expressed with the loss of electrolytes; Local in ophthalmic practice : keratit, allergic diseases and eye injuries.

Contraindications

Hypersensitivity, heart failure, hypertension, hyper-and hypothyroidism, osteoporosis, the violation of the liver and kidney failure, systemic and local mikozy, herpes, chronic infections, diabetes, saying disease divertikulit, mental illness, pregnancy and breast-feeding (at the end of treatment); For local use, fungal and bacterial destruction eye.

Side-Effects

Napochechnikovaya deficiency, male, erosion syndrome, raising glucose giperkaliemia, hypertension, headache, dizziness, euphoria, emotional lability, the vnutriglaznogo pressure (inwards Local), education cataracts (Local), menstrual irregularities, a slowdown in the growth of children, oedema.

Patient interaction

Increases efficiency (and toxicity) system gluko- and mineralokortikoidov reduces - anabolic steroids (but increases their gepatotoksicnosti), oral antidiabetics drugs. Do likely side effects in the appointment of cardiac glycosides, means of gipokaliemia (dioretiki, amphotericin B). While natrisoderjath drugs increases the risk of swelling and hypertension, aspirin, etc. NPVS - pitting nervous stomach. Psychotropic medicines and alcohol stimulate eliminatiu.

Overdosing

Symptoms : Already, gipokaliemia, hypertonic kriz, oedema, increased body mass index.

Precautions

There is a need for regular monitoring of AD in potassium and glucose in the blood. It should limit consumption of salt, as a prophylactic drugs potassium control functions napochechnikov crust. Extension rate can be achieved only if lower doses. After a long reception lifting out gradually (risk napochechnikova deficiency).

Dosing and Administration

Inside, ranging from 0.1 mg three times a week to 0.2 mg once a day. In napochechnikova chronic malnutrition and adrenoguenitalnom syndrome 0.1-0.2 mg / day, together with gidrokortizonom (10-30 mg / day), the long-term; Eye ointment; For a cat 1-3 times a day, no more than two weeks.

Directory → Hormones and their antagonists → Adrenal → Mineralokortikoida → Fludrocortisone