Kortineff

Roman name

Cortineff

The composition and the form of

Pill-1 tabl.fludrokortizona acetate 0.1 mgwo bottle dark glasses to 20 pcs. ; In a box one bottle.

Pharmacokinetics

Once inside quickly and completely absorbed from the digestive tract. There are in the blood within 10 to 20 minutes after administration of doses of 0.1 mg. C_max in whey is about 1.7 hours after administration. Linking blood protein is 42%. Metabolised mainly in the liver, in part, in the kidneys. Report from the body with the urine in the form of inactive metabolites. T_1/2 from plasma is about 3.5 hours from tissue-18-36 h. The preparation of 1-2 days.

Farmakodinamika

Increased vnekletocna liquid and sodium delay raise the AD. However, long-term use the AD to be more directly related to an increase in CSO than to the influence of the drug on vodno-elektrolitny Obmen.v doses exceeding therapeutic may inhibit activity crust napochechnikov, thymus gland and the secretion ACTG gipofizom. May increase glycogen storage in the liver, and with insufficient flow of protein food-result in negative nitrogen.

Indications

Primary lack crust napochechnikov (congenital dysfunction napochechnikov, Addison disease, the state of the full adrenalektomii), a lack of secondary crust napochechnikov, adrenoguenitalny syndrome loss of sodium gipovolemia and hypotension different genesis.

Pregnancy and lactation

Perhaps only if the effect of therapy outweighs the potential risk to the fetus. Women of reproductive age should be infolrmirovana the potential risk to the foetus. In the absence of crust napochechnikov reception Kortineffa during pregnancy should continue, and the dose will be able to grow. At the time of treatment should stop breastfeeding. Kortineff is with the mother's milk, and may cause the child's unwanted effects, such as delayed growth or oppression of endogenous hormones napochechnikov crust.

Contraindications

Hypersensitivity, incl. to the other components of the drug, systemic fungal infections (see also "Precautions").

Patient interaction

Heart glycosides : increased risk of heart rhythm and toxicity glycosides of Gipokaliemiei.barbiturata, противоэпилептически е drugs (phenytoin, carbamazepine), rifampicin, glutetimid up corticosteroid metabolism (by induction mikrosomaionah enzymes), weaken their �ействие.Антигистамин ные drugs weaken the �ортинеффа.Амфотерици н B inhibitors carboangidraza : gipokaliemia, Denmark turned left heart failure �ровообращения.Анабол ические steroids, androgena : increased risk of peripheral swelling, acne; use caution, especially in the case of liver disease and Serdza.perorale contraceptive preparations containing estrogena : increased concentration globulinov linking glukokorticosteroida in the serum, slow metabolism, increasing T_1/2 strengthening of �ортинеффа.Антикоагул янты (coumarin derivatives, indandion, heparin), streptokinase, urokinaza : reducing, and in some cases to improve efficiency; dose should be determined on the basis of protrombinovogo time; Increased risk of ulcers and bleeding from the Jkt.tricickliceskie antidepressants may increase personality disorders associated with hosting Kortineffa (not to appoint them to treat data �арушений).Пероральны�� antidiabetics preparations insulin : hypoglycemic effect of increasing concentrations of glucose in the blood (possible correction dose protivodiabeticakih �репаратов).Мочегонны�� Preparations : weakening of dioretikov (kalisberegath) �ипокалиемия.Слабител ьные means : reducing actions Gipokaliemia.efedrin may accelerate the metabolism �люкокортикостероидо�� (Correction possible dose �ортинеффа).Иммунодеп��ессивные Preparations : increased risk of infections, lymphoma and other limfoproliferativeh Zabolewanyi.preparata, neuromuscular blocker conductance (depoliarizute muscle) : gipocalziemia that use Kortineffa may reinforce the blockade of synapses, leading to an increase in the length of nervous Blokady.npvs, acetylsalicylic acid : easing actions increase the risk of gastrointestinal ulcers and bleeding from the Jkt.preparata food containing sodium : peripheral oedema, arterial hypertension (it may be necessary to limit sodium food and drugs with a high content of sodium. sometimes �люкокортикостероидо�� it needs more of sodium). The vaccine containing live viruses : between the doses of immunosuppressive �люкокортикостероидо�� can be replicated viruses and viral diseases; reducing the production of antibodies (simultaneous use is not recommended). Other vaccines : Increased risk of neurological complications and the reduction of the production of antibodies.

Storage conditions

List B. In a dry, the dark spot

Shelf life

3 years

The registration

013538/01-2001

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