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The groupUnder certain circumstances, the immune mechanisms that play an important role in protecting the body from harmful effects, which can cause unwanted reactions. Thus, the exclusion of transplanted tissues and organs linked to the immune incompatibility. When tissue incompatibility organism produces antigens to the alien tissue antibodies, which, together with limfoidnami cells of the damage and loss. The state-of-the-art disease (systemic lupus red, trombozitopenica purpura, nodular periarteriit, autoimmunny glomerulonefrit, Baby Ulcerative Colitis, rheumatoid arthritis, etc.) can be considered as the auto-immune process resulting from the release of the organism specific antigens. Under normal circumstances, those antigens are bound and immunopatologicakih reaction is not. In connection with the above reasons is the development of a new search for drugs that inhibit immunogenez quelling antibody products : as developed antibodies and the CD4 cells plazmaticakimi, immunodepressivna activity must have chemical compounds overwhelming proliferativee processes limfoidnykh (immunocompetent) tissues and depressing biosynthesis of nucleic acids. As it turned out, immunodepressantnoe influenced by many substances.
Classify them as follows : a person's immune response as a whole (such as cytostatics) providing specific immunodepressivne Effects (including antilimfocitarnaya serum) eliminate reactions accompanying immune processes, the �ротивовоспалительны�� and only partially immunodepressive effects (eg glukokortikoida).
Especially expressed immunodepressus activity inherent zitostatikam (see Protivoopujoleve means), alkilirutm Preparations (ziklofosfan, hlorbutin, tiofosfamid, prospidin, etc.) antimetabolitam (6-mercaptopourin, 5-ftorurazil etc.), certain antibiotics (aktinomicin etc.). Representatives of these groups are currently in use as immunosuppressants. A specific immunodepressantom azathioprine is close to building and Operation of the 6-mercaptopourino (antimetabolitu). Immune drugs can reduce the incompatibility of fabrics and to be very effective in the treatment of autoimmune diseases. However, current products do not have the selective action, and can be accompanied by side effects. They suppress production of interferon, oppressed blood (causing radiation, trombozitopenia, anaemia and even pancitopenia) possibly lowering the overall immune function, enabling secondary infection, the development of septicemia, in the long-term use may contribute to the development of malignant neoplasms. Immunosuppressants (cytostatics, including azathioprine, etc.) should be applied on strict condition with the necessary precautions.