Ticloral

Roman name

Cycloral

The composition and the form of

1 capsule contains cyclosporine 25, 50 or 100 mg; in the package st.1 50 ml reception inside-100 mg; in vials of 50 ml.

Of drugs

Immunodepressivne. Suppress антигениндуцированну ю production and secretion limfokinov (incl. interleikin-2-factor cell growth) T-limfozitami activated. It suppresses haematopoiesis and does not affect the processes of phagocytosis.

Indications

Preventing rejection of organs and bone marrow after transplantation treatment transplant rejection in patients who had been receiving other immunosuppressants, prevention and treatment response "to the transplant house."

Pregnancy and lactation

Not recommended during pregnancy (in the absence of clinical data). At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь.

Side-Effects

From the nervous system and sensory organs : headache, parestesia, convulsions, tremor, the consciousness of view, the motion activity; From the circulatory system and blood (blood, gemostaz) : arterial hypertension, anemia, trombopenia, haemolytic uraemic syndrome; From the metabolic : giperkaliemia, gipomagniemia, giperuriquemia, giperlipidemia; For part of the intestine : anorexia, nausea, vomiting, diarrhea, stomachache, pancreatitis, reversible functions of the liver (more transaminaz, cium); From the urogenital system : failure of the kidneys (more creatinine, urea), intersticialny argued; dismenorea, amenorea; Other : allergic reactions (skin rash), gipertrihoz, a sense of fatigue, male, oedema, increased body mass index, limfoproliferativee malignant disease.

Patient interaction

Impact klirens PREDNISOLONE. Together with the use of drugs and potassium kalisberegatmi dioretikami increased risk of giperkaliemii; With NPVS, aminoglikozidami, amfoteritinom B ciprofloksacinom, kolhitinom, trimetoprimom - nefrotoksicnosti risk. When combined with lovastatinom - mialgii and weakness. Improve concentration ziklorala plasma ketokonazol, some makrolida (including erythromycin, jozamitsin), doxycycline, oral contraceptives, propafenon, some terms (including verapamil, diltiazem, nikardeepin); Lower-barbiturates, carbamazepine, phenytoin, metamizol sodium, rifampicin; Sulfadimizin and trimethoprim with their on / in the introduction.

Overdosing

Symptoms : violation of the Pocek.lechenie : symptomatic, nespecificescoe (from the stomach wash). Haemodialysis and gemoperfuzia weak.

Dosing and Administration

Inside, dose setting and adjust individually, in accordance with clinical and laboratory variables. Capsule should swallow Zelikom.vesroslam : with organ transplants, for 12 hours before the operation in the dose of 10-15 mg / kg, which is divided into two reception. During the 1-2 weeks after the operation daily in the same dose, after which it gradually reduces controlled concentration of cyclosporine in the blood to maintain (2-6 mg / kg / day). In combination with glukokortikoidami or other immunodepressantami can be used smaller doses (3-6 mg / kg / day in the initial phase of treatment). Transplant bone marrow : preparation appointed day, previous transplants, and transplant period for up to two weeks at a daily dose of -15 mg / kg, then move on to supportive therapy (12.5 mg / kg / day). If any intake could require a higher dose or / in the introduction. Maintenance treatment are at least 6 months (preferably 6 months), after which the dose is gradually reduced so that, one year after the transplant treatment was discontinued. When the reaction "to the transplant master treatment should resume with mild chronic water should be used and applied small doses Preparata.detam over 1 year product appointed in the same doses, the adults (per 1 kg of body weight). During maintenance therapy dose should be reduced gradually until a minimum effective, which in remission period should not exceed 5 mg / kg / sut.

Storage conditions

caps. : List B. The temperature is not above 25 ° Cr-r reception inside : List B. The temperature is not above 30 ° C

Shelf life

caps. : 2 gu.r-r reception inside : 2 grams.

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