Ciclosporin gexal

Roman name

Ciclosporin Hexal

The composition and the form of

1 ml for admission into the cyclosporine 100 mg; Patients in the dark glass of 50 ml, complete with thick graduirovannam injection, in a cardboard package flakon.1 1 capsule - 25, 50 or 100 mg; in a contour acheikova packing 50 or 100 pc. , in a cardboard bundle one package.

Of drugs

Immunodepressivne. It stops cell activation and ingibiruet synthesis Cytokines.

Indications

Prophylaxis and treatment of rejection reactions after transplantation solid organs and transplant bone marrow, reactions "to the transplant master, rheumatoid arthritis, ranging uveit, principally syndrome, the severity of psoriasis and atopic dermatitis.

Pregnancy and lactation

When pregnancy is possible only for health reasons. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity; In the case, with the exception of organ transplantation, the kidney function (except from nefroticski syndrome), uncontrolled arterial hypertension, acute infectious diseases, malignant neoplasms; For the treatment of the deadliest form of psoriasis, threatening to the lives of liver disease and the highest levels of uric acid or potassium in the blood, of psoriasis, caused by the use of drugs, while the fotoaguirovanna hemoterapii, alcoholism, and eritrodermicakie pustulezne forms of psoriasis, multi-therapy metotrexatom, age under 18 years of age; for the treatment of the long-term or rezistentny to medication atopic dermatitis, rare forms of atopic dermatitis after the previous systemic therapy, including korticosteroidami, the fotoaguirovanna hemoterapii, child age; for the treatment of the rheumatoid arthritis-child.

Side-Effects

From the nervous system and sensory organs : fatigue, paresthesia, motor polineiropatia, tremor, convulsions, Engjefalopatia.so the circulatory system and blood (blood, gemostaz) : arterial hypertension, ischemic heart disease, anaemia, Lakopenia.so part of the intestine : Denmark gums, loss of appetite, nausea, vomiting, diarrhoea, gastritis, gastroenteritis, stomach ulcers, pancreatitis, colitis, raising cium and liver Fermentov.so the musculoskeletal system : rarely muscle weakness, Mialgia.so the urogenital system : violations of the kidney obratimaya dismenorea and amenorea, ginekomastia, Priliv.so the metabolism : forming an increase in the level of lipids in the cell, the increase in body mass index, giperglikemia, giperuriquemia, gout, giperkaliemia, Gipomagniemia.so the skin : Over owolosenie Koji.allergicakie reaction : red skin Zud.prochie : swelling of hyperthermia, malignant and limfoproliferativee violations.

Precautions

Be wary appoint sick elderly. There is a need to systematically monitor the kidney and liver, the level of potassium, magnesium in serum, AD.

Dosing and Administration

Inside, at the time of delivery, at the same time of day, capsules is not liquid, squeezed water; Oral solution pre-measured otmeraut gun and manage drinking water. Dose finish индивидуально.Трансп��антация Bodies : 10-14 mg / kg / day of 2 reception at intervals of 12 hours for 1-2 weeks after the operation, with a further decrease of dose to 2-6 mg / kg / day of 2 �риема.Трансплантация �ostny brain : 1-2 for the day before operation dose of 2.5-5 mg / kg / day in / in, before proceeding to the supportive therapy, in the dose of 12.5 mg / kg per day in two stages over a 3-6 month and the gradual decrease Dozy.terapia reaction "against transplant owner : -15 mg / kg per day in two stages over a 50 day, then declining rate of 5% during the week and the cancellation of therapy in 20 Ned.andogenny uveit : 5-10 mg / kg / day in two stages over a 3-16 Mes.psoriaz : 2.5-5 mg / kg / day in two stages over a 12 Ned.nefroticeski syndrome : 5 mg / kg / day until the effect dose then gradually reduce to the minimum effective; If the violation of the kidney initial dose of 2.5 mg / kg for 3 Mes.revmatoidnyi arthritis, atopic dermatitis : 2.5 mg / kg / day in 2 admission (with the lack of up to 5 mg / kg / day) for 6-8 weeks (dermatitis) or 12 weeks (arthritis).

Storage conditions

caps. : List B. The temperature is not above 30 ° Cr-r reception inside : List B. The temperature is not above 30 ° C

Shelf life

caps. : 3 gu.r-r reception inside : 3 g.

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