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Imuran

See also Azathioprine

Roman name

Imuran

The composition and the form of

Male Film-coated-1 tabl.azatioprin-50 megawatts blistere 25 pcs. ; In the box four blisters.

Pharmacokinetics

There is a very variabelnoe induction. Bioavailability 20%, as is fast becoming a 6-mercaptopourin (bioavailability of 60%). C_max-2 p.m. Creates high concentrations in the liver tissue and ulcers; Level in the kidneys, lungs, spleen, pain is such plasma. T_1/2-5 pm

Farmakodinamika

It stops the growth and development of immunocompetent cells (lymphocytes, plazmaticakih cells), on the cooperative immune response (T-limfozita-macrofagi-b-limfozita), oppressing migration of stem cells. In high doses (10 mg / kg) inhibits the bone marrow, suppressing the proliferatiou granulozitov is lakopeniu.

Indications

The transplantation of organs, severe rheumatoid arthritis, systemic lupus red, dermatomiozit, chronic active hepatitis, pemfigus vulgaris, nodular periarteriit, haemolytic anaemia, chronic idiopathic trombozitopenica purpura.

Pregnancy and lactation

Contraindicated.

Contraindications

Гиперчувствительност ь (incl. to 6-mercaptopourino).

Side-Effects

Mielodeprescia (lakopenia, thrombocytopenia, anemia), megaloblastny eritropoez and macrocitos, nausea, vomiting, anorexia, skin rashes, arthralgia, mialgii, drug fever, hepatitis holetsaticeski, development of secondary infections; Recipients of transplants - erosivno-azwenne defeat and bleeding from the stomach, pancreatitis, necrosis and perforation of the bowel, rarely, acute renal failure, haemolytic anaemia, acute lung disease, meningeale reaction.

Patient interaction

Do effect depoliarizuth miorelaksantov and weakens - nedepoliarizuth. Immunosupressiu potenziruut allopurinol, oksipourinol, tiopourinol.

Precautions

In the first eight weeks of therapy required weekly complete blood analysis. To use caution in case of renal and liver failure. When combined with a allo-, oxides, tiopourinolom dose should be reduced fourfold.

Storage conditions

Schedule A. In the dark place at a temperature of no higher than 25 ° C

Shelf life

5 years

The registration

013876/01-2002

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