Biaven v.i.

Roman name

Biaven V.

The composition and the form of

1 bottle with liofilizirovannam powder preparation infusions of normal human вирусинактивированно го immunoglobulin 500 mg, 1, 2.5 and 5 g; Patients in the 10, 20, 50 and 100 ml, in a Box 1 bottle (together with the solvent in vial). 1 ml prepared infuzing solution contains 50 mg of active substance.

Of drugs

Fills deficit opsonisiruth and neutralizing antibodies against bacteria, viruses, toxins and other infectious agents. Improves supressornuyu activity blocks receptors F_c (permanent part Ig) for macrofagah governs idiotipicescuu network of the immune system and cell activity, which leads to a decrease in IgG and reduce complement.

Pharmacokinetics

The on / Infusion in bioavailability is 100%; T_1/2 about 24 days.

Indications

Prevention and treatment (as a substitution therapy) infections in the primary immunodefitsitah : idiopathic agammaglobulinemia and gipogammaglobulinemia, variabelny and combined immunodeficita, Vizcotta syndrome - Aldric; In the secondary immunodefitsitah : HIV in pediatrics, chronic limfoproliferativee disease, multiple mieloma, bone marrow transplantation, infection in newborn and premature babies with low birth weight. Klebsiella or immunodepressivny syndromes autoimmune diseases. Autoimmune idiopathic thrombocytopenia and anaemia secondary to a systemic vasculites. Autoimmune neutropenia, ingibitornaya form of hemophilia. Demielinizirute diseases : AIDS Giyena-Barre polineiropatia, male, refrakternaya epilepsy in children, antifosfolipidnyi syndrome accompanied by sampirizvolnami pregnancy, red lupus, a disease Stilla, vasculita, Kawasaki syndrome.

Pregnancy and lactation

Valid only on the strict condition : long experience clinical application shows no adverse effect on the course of pregnancy, the foetus or newborn.

Contraindications

Homologues intolerance immunoglobulins, especially if the antibody IgA.

Side-Effects

Chills, headache, fever, artralgia, pain in the back, the decline AD, vomiting, nausea, allergic reactions (rare); Anaphylactic shock (very rarely).

Specific guidance

Infuziu only through individual system for the on / in the introduction. Perhaps breeding physiological solution of sodium chloride or 5% glucose solution. The mixing and co-administration with other drugs.

Patient interaction

During the month feature reduces the effect attenuated vaccines (measles, rubella, mumps, chicken pox).

Precautions

In the case of unwanted phenomena should reduce speed, or a stop infuziu before their disappearance.

Dosing and Administration

In / in the drip, with a speed of 10 to 20 drops / min for 20 min, and then possibly increase it to 40 drops / min depending on the переносимости.Замест��тельная Therapy : 100-400 mg / kg (2-8 ml) once a month; if necessary, 800 mg / kg (16 �л).Иммуномодулирующа�� Therapy : exchange-dose 400 mg / kg (8 ml) for a period of five days, or 1000 mg / kg (20 ml) for 2 days. When necessary repetition treatments to 6 Raz.transplantation bodies : before and after transplantation, in the dose of 500 mg / kg (10 ml) a week, then a month.

Storage conditions

por.liof.d / inf. : In the dark place at a temperature of no higher than 25 ° C. Do not freeze.

Shelf life

por.liof.d / inf. : 3 and

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