Immunoglobulin human normal

Of drugs

Drugs, the immunostimulating. Increases in the body antibodies. The on / Infusion in bioavailability is 100%. The plasma and space vnesosudistam place of preparation, and the balance is approximately 7 days. The individuals with the normal IgG in the serum period biological half averages 21 days, while in patients with primary hypothesis or agammaglobulinemiei-32 days. A wide range opsonisiruth and neutralizing antibodies against bacteria, viruses and other pathogens. The patients with primary or secondary immunodeficiency syndromes, the completion of the missing antibody IgG class, which reduces the risk of infection.

Indications

Substitution treatment for the prevention of infection with the syndromes primary immunodeficiency : agammaglobulinemii, conventional variabelnah immunodefitsitah of averting or gipogammaglobulinemiei; Deficit IgG subclasses, substitution therapy for the prevention of infections acquired in the secondary immunodeficiency syndrome caused by chronic limfoleikozom, AIDS in children or transplant bone marrow, trombozitopenica idiopathic purpura, Kawasaki syndrome (in addition to treatment with drugs acetylsalicylic acid), heavy bacterial, including sepsis (in combination with antibiotics), and viral infections, the prevention of infections in premature babies with low birth weight (less than 1,500 grams), Giyena syndrome - Barre and chronic vospalitelnaya demielinizirutaya polineiropatia, Autoimmune neutropenia, collective krasnocletocnaya aplasia blood, Immune thrombocytopenia origin, including posttransfuzionnaya purpura, thrombocytopenia izoimmunnaya newborns, haemophilia caused by the formation of antibodies to factor out, myasthenia gravis, prevention and treatment of reproductive tract infections and therapy zitostatikami and immunodepressantami, preventing migraine attacks.

Contraindications

Гиперчувствительност ь immunoglobulinam the rights, especially in patients with IgA deficiency through education to the antibodies.

Side-Effects

Headache, nausea, dizziness, vomiting, pain in the abdomen, diarrhoea, blood hypothesis or hypertension, tachycardia, zianoz, dizziness, a sense of sdavljenia or pain in the chest, allergic reactions; Rarely severe hypotension, collapse, loss of consciousness, hyperthermia, vomiting, increased sweating, a feeling of fatigue, malaise, back pain and mialgii, numbness, hot flashes, or feeling cold.

Specific guidance

The preparation should be stored at room temperature is above 25 ^ C, in the dark place, it is not advisable to freeze.

Patient interaction

Can reduce the effectiveness of the active immunization : live viral vaccines for parenteral application should not be used for at least 30 days after the imposition of immunoglobulin.

Precautions

Most of the side effects associated with a high rate of infusion and can be kupirovano to stop or slow infusions. In the event of a severe side effects introduction should stop (can be displayed adrenaline, protivogistaminne means corticosteroids and plazmozameniteli). If any of the kidneys to monitor the status of patients at the time of treatment (control-creatinine within 3 days after injection). Following the introduction of an immunoglobulin (passive) antibody in the blood, which can lead to erroneous interpretation of the results of serological study.

Dosing and Administration

In / in, drip. The mode set individually, depending on the evidence, the gravity of the disease of the immune system, individual endurance. In syndromes primary and secondary immunodeficiency single dose of 0.2 g / kg (average of 0.4 g / kg); Enter at intervals of 2-4 weeks (to maintain minimum levels of IgG in plasma, constituting 5 g / l). To prevent infections in patients who have a allotransplantation bone marrow, 0.5 g / kg once 7 days before transplantation, and then once a week for the first 3 months after transplantation, and once a month for the next nine months. При идиопатической тромбоцитопенической пурпуре - 0,4 г/кг 5 дней подряд; в дальнейшем (при необходимости) - по 0,4 г/кг с интервалами 1-4 нед для поддержания нормального уровня тромбоцитов. In Kawasaki syndrome - 0,6-2 g / kg in a number of techniques for 2-4 days. In severe bacterial infections (including sepsis), and viral infections - 0.4 g / kg daily for 1-4 days. To prevent infections in premature babies with low birth weight, 0.5-1 g / kg at intervals of 1-2 weeks. When presented syndrome and chronic inflammatory neuropathy demieliniziruta 0.4 g / kg for five days; If necessary, 5-day treatments are repeated at intervals of four weeks.

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