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Immunoglobulin

See also Immunoglobulin human normal

Roman name

Immunoglobulin

The composition and the form of

1 bottle with liofilizirovannam powders for the preparation of injection solution contains immunoglobulin 1, or 3 g; in a carton one bottle complete with the solvent in vials 16.5; 33; 100 ml (1 g) and 200 ml (for 3 g), and a one-time system for on / in a drip.

Of drugs

Immunoglobulin molecule contains two lungs and two identical heavy chains. Heavy polipeptidnye chain of five structurally and functionally different classes of immunoglobulins : IgG, IgA, IgM, IgD, IgE. When processing Ig proteinazami (enzymes, proteins decadent), in particular papainom receive three large fragment. Two of them identical and described as Fab (Fragment antigen binding -fragment linking antigen / substance, which can cause allergic reactions). The third piece is numbered Fc (Fragment crystalline - piece crystal). Fc fragment makes spectacular various functions antibody (blood proteins produced in response to falling into alien organism proteins and toxins) that have nothing to do with the specificity of the binding of compliments, interaction with Fc receptor macrophages (blood cells that can invade and destroy disease-causing germs), etc.

Indications

Gipogammaglobulinemia, autoimmunity, viral infection, severe systemic bacterial infection accompanied by septiko-toksicskimi complications, as a complement to antibiotikoterapii et al.

Contraindications

Hypersensitivity to immunoglobulinam rights, especially in patients with a deficit of IgA due to the presence of antibodies to IgA.

Side-Effects

Side effects of the introduction of immunoglobulin more likely in the first swell. They arose shortly after the infusion or within the first 30-60 minutes. There may be headache, nausea, less frequently, dizziness; In rare cases, vomiting, pain in the abdomen, diarrhoea (diarrhoea). Hypotension or hypertension (decrease or increase blood pressure), tachycardia (increase in serdzebieni sense sdavljenia or pain in the chest, zianoz (posinenie skin and mucous membranes), dyspnoea. There hyperthermia (increased body temperature), vomiting, increased sweating, a feeling of fatigue, malaise; Rarely back pain and mialgii (muscle pain), signs, tides or feeling cold. In extremely rare cases, there were severe hypotension, collapse (sharp decline in blood pressure) and loss of consciousness.

Patient interaction

We confuse living viral vaccines; Farmatsevticeski incompatible with other drugs.

Dosing and Administration

In / in, and substitution therapy, 0.1-0.3 g / kg every 3-4 weeks, autoimmune diseases - 0.4 g / kg / day for 2-5 days; Infections in neonatal and perinatal period, 0.5-1.0 g / day for 6 days.

Shelf life

por.liof.d / inf. : 4.5 g.

Indications for use

Substitution treatment (introduction to the substance / immunoglobulin / natural education which lowered or terminated), with the aim of preventing infections with syndromes primary immunodeficiency syndrome; Agammaglobulinemii (not gammaglobulinov / specific proteins involved in the formation of protective body / blood); Conventional variabelnah immunodefitsitah of agammaglobulinemiei; In the fiscal UgG divisions. Substitution treatment for the prevention of infections acquired in the secondary immunodeficiency syndrome, obuslovennom following conditions : chronic limfoleikozom (limfoidna cancer tissue), AIDS in children, transplant bone marrow. Idiopathic (immune origin) trombozitopenica purpura (multiple bleeding of the skin and mucous membranes associated with a lower content of platelets in the blood). Kawasaki syndrome (usually as a supplement to standard treatment with drugs acetylsalicylic acid). Heavy bacterial infections, including sepsis (blood poisoning microbes from home purulent inflammation), in combination with antibiotics, and viral infections. HIV infections in premature babies with low birth weight (less than 1,500 grams). Guillain syndrome and chronic vospalitelnaya demieliniziruuchaya polineypropatia. Neit-ropenia (lower content neitrofilnykh granulozitov in the blood) autoimmune origin and Autoimmune Hemolytic Anemia (reduction of hemoglobin in the blood as a consequence of the collapse of the high-cells in the blood). True eritrocitarnaya aplasia, through indirect antibodies. Thrombocytopenia (reduced platelets in the blood) Immune origin, such as postinfuzionnaya purpura, or thrombocytopenia izoimmunnaya newborns. Hemophilia (reduced blood coagulation) as a result of the formation of antibodies to factor R. Treatment myastenia gravis (disease nervous and muscular systems in the form of weakness and Pathological utomlemostew different groups of muscles). Prevention and treatment of infections in therapy zitostatikami (means preventing cell division) and immunodepressantami (means immunity shock / immune system). Prevention old fetus.

Form of

Liofilizirovannoe dry matter for the infusions in vials (= one dose), containing 0.5 g, 1 g, 3 g, 6 g, 10 g or 12 g of human immunoglobulin.

Storage conditions

List B. In the dark place at a temperature of no higher than 25 C. The drug should not be frozen.

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