Aldesleukin

Chemical name

125-L-Серин-2-133-интерлей��ин 2 (human restored)

Gross

C690-H1115-N177-O203-S6

Characteristics

Analogous interleikina-2, obtained by recombinant DNA technology using chain genes interleikina-2 gene; Chemically is : des-alanil-1, serine-125 interleikin-2 people. White or is not white, sterile, that does not contain preservatives liofilizirovanny powder.

Of drugs

The drugs-immunomodulirutee. Is limfokinom. Rekombinantnaya form differs from the natural interleikina (not glikozilirovana as obtained from the gene has no N-alanina final in the 125 tistein replaced by serine), but has full human activity interleikina-2. Activates cellular immunity. Immunoregulyatorne properties are enhanced mitogeneza lymphocyte stimulation and amount of growth interleykin-2 dependent cell populations increase Cytotoxicity cells, induction kletok-killerov (лимфоцитактивирован��ых and natural), and products gamma-interferon, Necrosis Factor tumours, �нтерлейкина-1.Создает �asokie plasma concentration after a brief on / in Infusion quickly penetrate and ekstravasculiarnoe vnecleterne space and excreted kidneys. There is a two-phase eliminatiu : T_1/2 in the first phase, 13 minutes, the second 85 minutes.

Indications

Metstatical renalnaya cell carcinoma, melanoma (additional therapy).

Contraindications

Hypersensitivity, the violation of breath, and ECOG status less than 2, the status ECOG 1 and the liturgy more than one body, less than 24 months after the initial diagnosis of primary tumours, metastases in the central nervous system, severe cardiovascular diseases, infectious diseases, requiring antibiotikoterapii, sudorozhny syndrome, autoimmunity, lakopenia (less than 4000/mmo ^ 3) thrombocytopenia (less than 100000/mmo ^ 3), pregnancy, breast-feeding (at the end of treatment), reproductive (requires a reliable contraception), and child.

Side-Effects

Arterial gipotenzia, adults, tachycardia, migraine pain; Cough, cough, despnoe, tahipnoe, pneumothorax, a breach of taste, diarrhoea, neuralgia, stomatita; Raising cium, transaminaz, alkaline phosphatase, liver, gepatomegalia, changing functions of breathing, mental status and consciousness, memory disorders, visual, speech, motor dysfunction, coma; Mialgii, arthralgia, arthritis; Oliguria, anuria, proteinurija, gematuria, dizuria, anemia, thrombocytopenia, lakopenia, leucocytosis, discoagulyatsia, eozinofilia; giperglikemia, giperkaliemia, gipocalziemia, increased body mass index, skin reaction-erythema, itching, alopecia.

Specific guidance

Ready solution must be clean, colourless or svetlo-jeltam. Bubbles single application, so neisrashodovannoe substance to be destroyed. During preparations solution sterile water for injection should be poured gently on the glass, avoiding vspenivania. No shaking! Divorced aldeslakin should be used within 48 hours previously heated to room temperature.

Patient interaction

Effect reduce glukokortikoida. Beta-adrenoblokatora increase hypertension hypotension. Gepato-, nefro-, mielo- and cardiotoksicnae drugs increase (each), the likelihood of side effects.

Precautions

In the case of side effects infuziu should stop until the disappearance of toxic reactions, and then resume in half dose. Be sure to pass patients before and after therapy following tests : standard induce study measuring the amount of loose blood biochemical analysis of blood analysis elektrolitnogo composition, and kidney pechenocnami functional tests, a chest radiograph. Since aldeslakin stimulates secretorne processes serozhnykh envelopes increasing effusion in cavities, it is necessary to the course of therapy, and during his monitor the functional state of the lungs, the treatment of opportunistic infections. Be wary appointed in old age.

Dosing and Administration

The first induction cycle (adult), continuing Thalgo in / in cefuroxim dose of 1 mg / m ^ 2 per day, after 2-6 midday break a five-day infuziu repeat in the same dose; Second induction cycle through three weeks. The patients with positive dynamics can be up to four cycles of induction.

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