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Glatiramer acetateCharacteristicsMixture of synthetic polipeptidov formed by amino acids (L-glutaminova acid L-alanin, L-tirosin and L-lizin).Of drugsThe drugs-immunomodulirutee. Does the major myelin protein, as well as oligodendrocitarian glikoproteinom myelin and proteolipidnam for protein binding to molecules main histocompatibility complex class II on the surface of cells are antigens. Promotes Education антиген-специфически�� T. Does mielin-specificskie autoimmunity behind the destruction caused nervous system fibers (demyelination) to spread Sklerose.pri treatment of patients with multiple sclerosis relapsing course reduces the frequency of relapses and slows growth irreversible neurological нарушений.Мутагенног�� is not found. In experiments on rats with p / to a dose 18 times higher than MRDC not have adverse effects on reproduction. When s / to a pregnant rats and krolikam during organogeneza doses up to 37.5 mg / kg, there has been a negative influence on the development of the embryo / ploda. In pre - and postnatal studies in the s / by the introduction of rats doses 18 times higher than MRDC, in the period from 15 days of pregnancy and during lactation, there has been significant impact on the birth, growth and development Ploda.neizwestno infiltrates whether glatiramer acetate in breast молоко.Фармакокинети��еских Studies in humans have not. Experimental animal studies suggest that a significant number of imposed p / to glatiramer acetate Local hydrolyses, some up the lymphatic system, a small part is in the system in the bloodstream unaltered.IndicationsMS relapsing current.Restrictions on the use ofPregnancy, breast feeding, child age (safety and efficacy of up to the age of 18 are not defined).Pregnancy and lactationPerhaps if the effect of therapy outweighs the potential risk to the foetus and the child (adequate and well-controlled studies safety of the pregnant and lactating women did not).ContraindicationsHypersensitivity, incl. mannitu to.Side-EffectsVazodilatation, hyperemia, pain or weight in the chest, heart, the AD, anxiety / anxiety, weakness, dizziness, nausea, difficulty glotania, artralgia, limfadenopatia, urticaria (arise immediately after injection of approximately 10% of the cases were independently and do not require special treatment). Local reactions : pain at the injection, redness, swelling, itching of the skin.Patient interactionCompatible with glukokortikoidami.Dosing and AdministrationP / to 20 mg once a day, every day at the same time. Treatment long.See also |
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