Poliauxidoni injection

Roman name

Polyoxidonium pro injectionibus

The composition and the form of

1 USD or 1 bottle with liofilizirovannam powder for injection contains poliauxidonia 3 or 6 mg; in a Box 5 pcs.

Characteristics

Synthetic drug-copolymer N-oksida and 1,4-etilenpieperazina (N-карбоксиэтил)-1,4-эти��енпиперазиния bromide is a liofilizirovannuu porous mass with a yellowish sheen, rastvorimuu well in the water.

Of drugs

Immunomodulirutee, desintoksikatine. Directly activates faguoqitirute cells and natural killera, stimulates antiteloobrazovanie increases products Cytokines has immunocorrigirutee influence. Increases resistance cell membranes to zitotoksicsky to various substances, including and medicines, reducing their toxicity.

Pharmacokinetics

Characterised by high biodostupnostthew (89%); C_max blood in the / m is a 40 minutes; Rapidly distributed to all organs and tissues; T_1/2 (rapid phase), 25 min, T_1/2 (slow phase), 36.2 hour with the / m and 25.4 h, with the on / in the introduction. The body is biodegradable, displayed mainly kidneys.

Farmakodinamika

Increases resistance organism in the local and Generalized infections, restores the immune status of the organism in immunodeficiency states.

Indications

The adults in the secondary immunodeficiency states in the treatment of : retidivirute chronic inflammatory diseases resistant to traditional therapy; Acute and chronic viral and bacterial infections; Allergic diseases (pollinoz, bronchial asthma, atopic dermatitis), acute chronic retidiviruta bacterial and viral infection; Local and Generalized forms septic diseases; Tuberculosis; acute and chronic �нфекционно-воспалите льные diseases of the genital and urinary system in men and women (prostatitis, Baby, medicine, anesthetic, salpingooforit, Dysmenorrhea, obesity viral and non-infectious etiology, ectopia cervix, diseases caused by the papilloma virus). For the prevention and treatment of local and Generalized Forms surgical diseases, post-operative complications; chemotherapy and radiation therapy to reduce Opouholei.dla nefro- and gepatotoksicski of medicinal Preparatov.dla regeneratornah activation processes (fractures, burns, trophic ulcers). In order to correct the secondary immunodeficiency caused by ageing or adverse Factorov.u children older than 6 months with secondary immunodeficiency states in the treatment of : chronic and acute inflammatory disease caused by bacterial infection, viral and fungal infections; acute allergic and �оксико-аллергические �ostojania (in combination with tavegilom and other drugs); bronchial asthma, aggravated chronic infections respiratory tract; atopic dermatitis, oslojnenny abdominal infection; goiter bowel.

Pregnancy and lactation

Contraindicated in pregnancy.

Contraindications

Hypersensitivity, pregnancy.

Patient interaction

It is combined with antibiotic, antiviral, fungicide and antihistamines preparations bronholitikami, korticosteroidami, beta-adrainomimetikami, zitostatikami.

Dosing and Administration

Adults : in the / m or / in (drip), single-dose 12 mg once a day, every day, every other day, 2 or once a week, depending on the diagnosis and severity of the disease. For the / m contents of sealed bottle or dilute 1.5-2 ml of water for injection or izotoniceski solution of sodium chloride; For a / in the drip-content sealed bottle or dilute 2-3 izotoniceski ml solution of sodium chloride, or gemodesa reopoligliukina, sterile into a bottle with the solution of 200-400 Ml.rastvor for injecting storage is not �одлежит.Рекомендуемы е regimens Vesroslah.ostrae inflammatory diseases - 6 mg daily for 3 days, followed by one day course 5-10 Ingyektion.hronicescie inflammatory diseases - 5 injections to 6 mg a day, hereinafter twice weekly rate 10 Ingyektion.tuberkulez-to 6 mg twice weekly rate 10-20 Ingyektion.ostrae and chronic diseases of the genital and urinary system - to 6 mg, course-10 injections a day, in combination with antibacterial �репаратами.Хроническ ий recurrent herpes - to 6 mg a day, a course-10 injection, in combination with antigerpeticakimi preparations interferonami and inductorami �нтерферонов.Осложнен ные forms of allergic diseases, and 6 mg Course 5 injections (2, the first day, then every other day). Severe allergic and �оксико-аллергические �ostojania in / in the 12 mg combined with tavegilom etc. p ротивоаллергическими п �епаратами.Онкологиче ские з abolevania before, and in the face of chemotherapy 6-12 mg a day rate of at least 10 injections. To prevent immunodepressivnogo of tumours, immune correction after chemo-and radiation therapy for the 6 mg 1-2 times a week for 2-3 months until 1 Goda.detam of 6 months : in the / m or / drip in the dose of 0.1-015 mg / kg once a day after one day course 5-7 injection. For the / m of 3 mg drug dissolved in 1-1.5 izotoniceski ml solution of sodium chloride. The on / in the 1.5-2 ml of sterile solution of sodium chloride izotoniceski, poligliukina, gemodesa or glucose sterile moved into bottles with the solution of 150-250 Ml.sublingwalno daily once a day dose of 0.1-015 mg / kg within 10 Dnei.intranazalno daily once a day dose of 0.1-015 mg / kg for 10 days. Each move forward depending on the 3-5 drops (in the appointment of more than 10 drops depending on Batches 3-5 drops in 10-15 minutes). The sublingual and intra of 3 mg poliauxidonia dissolved in 1 ml of distilled water (0.15 mg-1 drop), and apply the calculation of the weight. Solution stored in the refrigerator no more than one Ned.rekomenduyemye regimens Detei.ostrae inflammatory diseases, in / m, 0.1 mg / kg every other day course 5-7 Ingyektion.hronicescie inflammatory diseases, in / m, in the 0.1-015 mg / kg twice weekly rate 7-10 Ingyektion.ostrae allergic and токсико-аллергически�� the in / in the drip in the dose of 0.1-015 mg / kg in combination with tavegilom et al. �ротивоаллергическим�� репаратами.Осложненн ые forms of allergic disease (in combination with standard therapy), in / in drip or / m 0.1 mg / kg rate five injections at intervals of 1-2 Dna.disbacterios bowel-subilgvalno daily 0.1-015 mg / kg for 10 days.

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