Proleikin

Roman name

Proleukin #

The composition and the form of

1 bottle with liofilizirovannam powder preparation infusions (1 mg / ml) contains aldeslakina 1.2 mg (18 million IU / mg); in a box 1 and 10 pcs.

Of drugs

Immunomodulirutee. Aldeslakin and degenerative sinteziruemy limfokin (human SILT-2) have the same biological activity. Activates endogenous immune protection, helping to transform T, лимфокинактивированн ых killernah cells and �пухоль-инфильтрующих �imfozitov in killernae cells that recognize, thighs and destroy cancer cells. Increases products gamma-interferon and Necrosis Factor tumors.

Pharmacokinetics

The on / bolusnom in a curve of a bieksponencialny nature. T_1/2 in the first phase, 13 minutes, the second 85 minutes. Report the news.

Indications

Kidney disease (with cancer).

Pregnancy and lactation

Perhaps if the expected effect on the mother than the risk to the fetus. The Association should decide the question of the termination of breastfeeding.

Contraindications

Hypersensitivity, the status of patients ECOG equal to or greater than 2, ECOG status equal to or greater than 1 and metstaticescoe defeated more than one body, a period of less than 24 months between the initial diagnosis of primary tumors and the onset of therapy Prolakinom, heavy cardiovascular diseases (incl. disorder), severe infections that require antibiotic therapy, disease in the CNS, apnoea seizures, autoimmunity, lakopenia (less than 4000/mmo ^ 3), thrombocytopenia (less than 100000/mmo ^ 3).

Side-Effects

From the cardiovascular system : Gipotenzia, adults, tachycardia, stenocardia, rarely myocardial infarction, thrombosis, hypertension, heart, tranzitorne changes in the Ekg.so the urogenital system : oliguria, Gematuria.so part of the respiratory system : dizziness, swelling lungs, a cough, rarely respiratory distress adults zianoz, hypoxia, infectious Zabolevania.so part of the intestine : giperbilirubinemia, raising transaminaz and alkaline phosphatase, nausea, vomiting, diarrhoea, anorexia, disfagia, neuralgia, gastritis, obstipation, rektale Krovotechenia.so the nervous system : anxiety, agitation sputannosti consciousness, dizziness, drowsiness, and rarely parestesia, Basslines, depression, hallucinations, paralysis, speech disorders, Konwulsii.so the Skin : erythema, skin rashes, eye inflammation mucous membranes, itching, peeling, it is rarely alopecia, hyperemia Nos.so the blood : anemia, thrombocytopenia, lakopenia, rarely bow and rektale Krovotechenia.prochie : increases in the body, swelling, fever with outwardly, headache, rare pain in the joints, mialgia, liver, giperglikemia, gipocalziemia, giperkaliemia, flebit.

Patient interaction

Gepatotoksicskie, nefrotoksicskie, mielotoksicskie and cardiotoksicskie drugs increased side effects glukokortikoida reduce toxicity and therapeutic effect. Antigipertenzivee tools like beta-blokatora reinforce hypotension.

Precautions

It should be used only under the supervision of a physician. Not recommended male and female persons of reproductive age if they are not using contraception.

Dosing and Administration

In / in the drip. Adults - 1 mg / m ^ 2 in the form of 24 hours of continuous infusions over five days, then break 2-6 days, in the next five days to keep under / in infuziu (induction cycle). After 3-nedelnogo suspension should hold second induction cycle. Patients who have marked therapeutic effect, it would be advisable to maintain four cycles (1 mg / m ^ 2 in a 24-hour continuous infusions over five days). The contents of bottle Proleikina injection should engage in 1.2 ml of water for injection. The solvent type of bottle wall (to avoid flushing), and cautious pokachivaniami completely dissolved contents. Not shaking. The resulting solution must be a transparent colorless liquid. Under the above breeding in 1 ml containing 1 mg. Daily dose rastvorennaya in water for injection, if necessary, opened in 500 ml 5% dekstrozy for injection, with the addition of 0.1% human albumin (to prevent loss of bio). Human albumin should be added and mixed with dekstrosa injection before adding Proleikina. When severe anaemia infuziu should be interrupted until the complete disappearance of toxicity. Resumed introduction to the use of 50% of the initial dose.

Directory → Immunotropona funds → Immunomodulators → Proleikin