Remikeid

Roman name

Remicade #

The composition and the form of

1 bottle with liofilizirovannam powder for solution for the on / in the infliximaba contains 100 mg.

Of drugs

Immunomodulirutee. Interacts with the soluble and transmembranna forms of Tumor Necrosis Factor alpha (zitokin the biological effects), and reduces the functional activity, as a result of sustainable complex.

Indications

Rheumatoid arthritis (active form), ulcerative disease (active form).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (including other proteins ACME), sepsis, clinically expressed infection or abscess, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : depression, paranoia, anxiety, amnesia, fatigue, nervousness, drowsiness, headache, dizziness; Conjunctivitis, keratokongunguit, Andoftalmit.so the circulatory system and blood (blood, gemostaz) : tides, petehii, ekhimoz / bruise, giper-/gipotenzia, fear, throm, aetiology, rapid heartbeat, patients receptacles zianoz violation of peripheral blood circulation, incredible; Anaemia, leiko-, limfo-, stoichiometric, thrombocytopenia, limfozitos, Limfadenopatia.so the respiratory system : infection with upper respiratory tract infections, bronchitis, pneumonia, shortness of breath, sinusit, active bleeding, bronhospazm and other allergic manifestations, pleurisy, a swelling Legkih.so part of the intestine : halit, neuralgia, jeludern-pishchevodny reflux, nausea, diarrhoea or constipation, pain in the abdomen, divertikulit, holetsistit violation of Pecheni.so the urogenital system : swelling, infection urinary tract, incl. medicine; Waginit.so the skin : skin rashes, itching, urticaria, sweating, dry skin, dermatitis gribkovi (onihomikoz, eczema), seborrhea, birthmarks, warts, furunkoulez, giperkeratos, pigmentation of skin, alopecia, bulleznaya Sapi.prochie : mialgia, artralgia; periorbitalny swelling, education IgG, volchanochny syndrome; develop infections (influenza, herpes, fever, abscess, cellulite, sepsis, bacterial and fungal diseases); Tank and pain syndrome (pain in the chest); reaction at the beginning and others allergic reactions.

Specific guidance

Previously the contents of each bottle dissolved in 10 ml of water for injection, the syringe needle with 0.8 mm or less, and then cooked solution brings to 250 ml 0.9% solution of sodium chloride injection (to be introduced no later than three hours after cooking). Troop solution is not compatible (not to be confused) with other drugs.

Patient interaction

Methotrexate reduces antibodies to the drug and increases his concentration.

Precautions

Prior to the start of treatment to cure manifestnye infections and abscesses. In heavy infections, or sepsis therapy should be discontinued. During treatment must use reliable methods of contraception. Use antigistaminnah drugs and paracetamol to prevent (premedikation) or edema allergic reactions. It should refrain from the use of the drug in children and adolescents under the age of 17 years because the safety and efficacy of their use in children has not been quantified.

Dosing and Administration

In / in, and at speeds of up to 2 mL / min for a period of not less than two hours using infuzionna system apirogennam filter with a low belkovosvazavatei activity. In revmatoidnom arthritis : in one dose of 3 mg / kg, followed by 2 and 6 weeks after the first application and a further 8 weeks (total issuance, 5-6). In ulcerative disease (active form) : 5 mg / kg once; In the formation of fistulas, repeated at two weeks and six weeks after the first injection. In repeat diseases, adding a possible no later than 14 weeks.

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