Thymogen

Chemical name

Glutamiltriptofan

Of drugs

The drugs-immunomodulirutee. Simulate effects timopoetinov - stimulates cell factors immunogenesis, proliferatiou and differentiation of lymphocytes predecessors in immunokompetentne mature cells normalizes T-helpera/t-supressora ratio increases the concentration Zamf in predschedstvennikah cell. Do nespecificescuu resistance contributes to the activation of faguoqitarnah Klebsiella and monocytes / macrophages; Interferonogenez stimulates and the natural concentration (in low doses). And antimediatoriani properties. Vsokoeffectiven in immunodefitsitah T-supressonego type.

Indications

Heavy retidivirute (bacterial and viral) infections of the skin, urinary tract, respiratory tract and the lack of thymus (congenital or acquired). Immunodeficita (primary, secondary T-kletocnae and combined form) : the X-ray irradiation, chemotherapy, AIDS, autoimmune diseases, etc.; Multiple sclerosis, chronic diffuse liver damage, gastrointestinal diseases, including salmonellosis (combined therapy severe), chronic infections (in combination with antibiotics), psoriasis, perioperaie infectious complications (prevention and treatment).

Contraindications

Hypersensitivity, pregnancy.

Side-Effects

Marital ovaries (dismenorea, Cravings following the lifting of the drug), increasing neirodermita and eczema, swelling Kwinke.

Patient interaction

Increases the other kinds of therapy (cytostatics, Radiation Therapy, etc.).

Precautions

The drug is used under the supervision of immune status. Is not recommended, as the infection or acute infection period Prozessa.pered timogena appointment within 10 to 14 days to a stimulant leikopoaiza (metilurazil, pentauxil, leucogen, sodium nukleinat) to strengthen ejection from the bone marrow predshedstvennikov cells.

Dosing and Administration

V / m to 100 µ g within 10 days. Suggested schemes : 1) daily for five days, then one injection in 5 days; For a course of injections in 1910; 2) daily for 10 days, the maintenance therapy every five days; At the rate of 15 to 20 users; 3) daily for 3 days, followed by a break of 3-5 days; in the course 7-10 injection. Repeated courses can be a 3-5 month. Intranasal children under 1 year to 10 µ g, 1-3 years in the 10 to 20 micrograms, 4-6 years, 20 to 30 mg, 14 years, 50 µ g for 3-10 days, depending on the extent immunodeficiency syndrome. In minutes, in the / m to 1 ml of 0.01% solution every day for 10 days. Chronic diffuse liver disease in / m to 100 mg / day 5 days. In bronchial asthma and non-inflammatory lung diseases in children : up to 1 year, 0.1-0.3 ml (10 mg); 1-3 years, 0.3-0.5 ml (30 mg); 4-7 years - 0.5 - 0.8 mL (40 mg); 7-14 years - 0.8-1.0 mL (80 mg) in / m, c / or to the route, daily for five days, then one injection in 5 days; for a course of injections in 1910; re-rate after one month.

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