Choline theophyllinate

Chemical name

(2-Гидроксиэтил)тримет иламмония theofillinova salt (1:1)

Gross

C12-H21-N5-O3

Of drugs

Drugs, the skin. Ingibiruet fosfodiesterzu contributes to the accumulation in the tissues Zamf hampered connection with miosina aktinom reduces Oxytocics activity smooth muscles, in particular, relaxes spasms. Oppressing transport calcium ions through channels slow cell membranes, blocking receptors adenozinove has holinoliticski action. After intake of rapidly absorbed, distributed in vnekletocna liquid and evenly in all tissues. Therapeutic concentrations in the blood of 8-20 µ g / J For most patients the drug concentration in the serum of more than 20 µ g / ml was toxic. 55-65% associated plasma protein. T_1/2 averages 4.5 hours 10% of the interior of dose excreted in the urine. Equilibrium concentration in the blood in the course of 1-2 days. The smoking patients Cl drug improved by stimulating liver enzymes involved in its metabolism. Relaxes smooth muscles (including hospital), provides a stimulating effect on the central nervous system, increased airway diseases and skeletal muscles, increases diurez, jeludocnuu secretion. Is increase in the level of protrombina fibrinoguena and in the blood (protrombinovoe shorter time).

Indications

Prevention of bronchospasm in bronchial asthma and other chronic obstructive lung diseases, pulmonary hypertension, including emphysema in the lungs.

Restrictions on the use of

Heavy lung and heart disease.

Contraindications

Hypersensitivity, saying disease stomach and duodenal ulcers in the phase of deterioration, disease.

Side-Effects

Nausea, vomiting, diarrhoea, pain in epigastria, increased losses erosivno-yazvennah stomach, headache, sleep disturbance, tachycardia, demotion AD up to the collapse, lakopenia, thrombocytopenia, contact dermatitis, urticaria, skin itch.

Patient interaction

Erythromycin increases in plasma and toxic. Do cardiale effects of cardiac glycosides and the dioreticescoe tiazidov is kumarinovykh antagonist anti reduces urikozuricescuu activity probenecida pirazolonovykh and derivatives. Preparations acidifying urine, weaken and podschelacivate-increasing effect.

Precautions

There should be appointed with other xantinami simpatomimeticakimi and amines.

Dosing and Administration

Inside. The mode set individually, in the light of evidence and the sensitivity of the patient : adults initial dose average 200-400 mg four times a day; Supporting daily intake - 800-1200 mg. Children aged between 10 and 14 to 22 mg / kg / day 4 admission, the average handle daily intake - 22 mg / kg in four reception.

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