Spofillin retard 100

Roman name

Spophyllin retard # 100

The composition and the form of

1 tablet retard (prolonged action) contains theofillina 100 or 250 mg; in a carton blisters 5 to 10 pcs.

Of drugs

Bronhodilatirtee, sossoudorasshiratee, cardiotonicescoe, dioreticescoe. Ingibiruet fosfodiesterzu and increases the Zamf in cages competitive adenozinove blocks receptors. Affects Intracytoplasmic of calcium, reduces the release gistamina lakotrienov and reduces synthesis and the effects of GHGs emission increases endogenous catecholamines.

Pharmacokinetics

It absorbed in the digestive tract. Linking plasma protein-60% (of children and the sick cirrhosis of the liver, 35%). Penetrates through the placental barrier in breast milk. C_max through 6900 (children - 6700), T_1/2 10-15 hours Therapeutic concentrations in the plasma of 10 to 20 µ g / J Metabolised in the liver. Return with urine (unchanged to about 10%).

Farmakodinamika

As a result of increased motor activity resnitchatogo covering the trachea and bronchi, stimulation respiratory centre and bronhodilatace increases and improves alveoljarnuu ventilation. Do airway cardiac muscles, stimulates secretornuu the stomach increases the central nervous system tone, moderate increases lung, renal and coronary vessels. Relaxes smooth muscle and blood of psoriasis.

Indications

Bronchial asthma, bronchoobstructive syndrome, c 8117 hronic respiratory distress with gipoventilaciei, bronhiolita in children.

Contraindications

Hypersensitivity, saying disease stomach and duodenal ulcers, bleeding in the digestive tract, liver failure, heart attack, irregular, gipertrofica obstructive cardiomyopathy, thyrotoxicosis, epilepsy, glaucoma.

Side-Effects

Nausea, vomiting, jeludern-pishchevodny reflux, gastrointestinal bleeding, headache, insomnia, anxiety, convulsions, tahiaritmia, allergic reactions.

Patient interaction

Zimetidin, allopurinol, ciclosporin, makrolida, oral contraceptives and anti-vaccine increased concentration in plasma; Phenobarbital, phenytoin, xantinove drugs, other induktora mikrosomalnogo oxidation - less. Do dioretikov effect reduces - propranolola, pirazolonovykh derivatives probenecida, kumarinovykh anticoagulants.

Dosing and Administration

The inside is not liquid for 30 minutes before eating, to 250 mg twice a day (at night attacks suffocation evening dose increase 1.5-2 times and take 22-24 hours). Children (weighing up to 30 kg) 10-20 mg / kg / day for 2 admission.

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