Theofillin

Roman name

Theophylline

Of drugs

Theofillin affects the various functions of the organism. He has a stimulative effect on the central nervous system, but expressed less than caffeine; Oxytocics strengthens the heart (cardiac muscle). Several more peripheral, coronary (heart), and renal vessels, is a moderate dioreticescoe (diuretic) Effects ingibiruet agregatia (from Figure) platelets, inhibits release of fat cells mediators allergies. Particularly important is the ability to theofillina bronhorasshirauchi effect. The mechanism of action theofillina play a role inhibition fosfodiesterzy and accumulation in the tissues of cyclical 3-5 -adenosinmonofosfata. The accumulation in the cells Zamf down miosina connection with aktinom, which reduces Oxytocics activity smooth muscles (muscles vessels and internal organs), and contributes to, among other things, relax the bronchi and the lifting of bronchoconstriction (narrowing clearance bronchi). To relax muscles have the ability to oppress theofillina transport calcium ions through "slow" channels of cellular membranes. Of particular importance in the molecular mechanism of action theofillina has revealed recently its ability to block adenozinove (purinove) receptors.

Storage conditions

List B. The well ukuporenna packaging keeps from the world.

Indications for use

Basically theofillin apply both bronchodilatory (extending clearance bronchi) tool, as well as a moderate force cardiotonicescoe (adding the heartbeat) and dioreticescoe (diuretic) is the stagnation heart and kidney origin. Sometimes shall, together with other inflammatory and bronholiticakimi drugs.

Dosing and Administration

Is the inside of 0.1-0.2 g (adults) 2-4 times a day after meals. Best effects frequently observed in the employment drug in the form of rectalnah (to give rectum) candles, as theofillin least be in the way of metabolizmu (turn) in the liver. Rektalno (in the rectum) introduce adults to 1 svece 1-2 times a day. Length of theofillina depends on the nature, characteristics course of the disease and the impact of therapeutic effect. Children 2-4 years appoint 0,01-0,04 g 5-6 years 0,04-0,06 g 7-9 years 0,05-0,075 g, 10-14 years 0.05-0.1 g per reception. Children under the age of two, is not appointed. Higher doses for adults inwards and rektalno : single 0.4 g daily 1.2 g.

Side-Effects

In some cases, there are side effects : indigestion, nausea, vomiting, diarrhea, headache pain. When using candles to stinging sensation in the rectum. If poorly portable product repeal. In theofillina overdose may arise epileptoidnye (apnoea) seizures. In order to prevent such side effects is not recommended theofillin term.

Form of

Powder; Candles 0.2 g.

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