Ventaks

Roman name

Ventax #

The composition and the form of

1 capsule contains retard theofillina anhydrous 100, 200 or 300 mg; blistere in 10 pcs. , in a package 2 blisters.

Of drugs

Bronhodilatirtee, dioreticescoe. Ingibiruet fosfodiesterzu and increases intracellular concentration Zamf; Blocking the release of inflammation mediators and the adenosine stimulates breathing centre normalizes perfuzie processes in the lungs, increasing the release of adrenaline and norarenalina glands, frequency and force of heart, stimulates the secretion of gastric juice. Increases kidney and blood clubockovu filtering diurez increases.

Pharmacokinetics

Quickly and completely absorbed from the digestive tract. Bioavailability-88%. Bronhodilatiruty effect in a concentration theofillina 5 µ g / ml and a growing proportion to the increase in the logarithm of concentration. Linking plasma protein is about 60%. Penetrates through the placental barrier, it is found in human milk. Metabolised in the liver. T_1/2 non-smokers, 10 hours, smokers-4-5 hour longer in the lung and heart failure, liver problems, viral infections, fever. About 10% of kidney displayed in an unmodified form.

Indications

Bronhospazm (treatment and prevention) in chronic obstructive lung diseases, bronchial asthma, breathing disorders central genesis, night ventricle, pulmonary hypertension, legern-serdecnaya failure.

Pregnancy and lactation

During pregnancy (especially in the teaching trimester) may use the presumed benefit to the mother outweighs the potential risk to the fetus. Be wary lactoirutm appoint women (because theofillin out with breast milk, it is desirable to suspend breastfeeding).

Contraindications

Гиперчувствительност ь to the components, epilepsy, a disease hospital of stomach and duodenal ulcers (acute phase), a children's age (up to 6 years).

Side-Effects

Rarely, nausea, vomiting, diarrhoea, headache, anxiety, arousal, sleep disturbance, tremor, heart feeling, incredible.

Patient interaction

Reduces activity beta-blokatorov, lithium salts. Effect increase furosemide, beta_2-adrainomimetiki, metilxantina, ephedrine and efedrinsoderjaschie products; Were, moreover, increase the risk of developing side effects. Phenobarbital, rifampicin, phenytoin, carbamazepine, sulfinpirazon, smoking increases Cl theofillina and makrolida, linkomicin, allopurinol, beta-blokatora, zimetidin, oral contraceptives, reduce diversion.

Dosing and Administration

The inside is not liquid, squeezed enough liquid. Adults, 300 mg after meals twice a day (morning and evening). The first appointment for patients weighing 60 kg and above beginning with the gala reception 200 mg, followed by 200 mg twice a day; with the mass of less than 60 kg, from the Evening Reception 100 mg, followed by 100 mg twice a day; dose gradually increased to 200 mg / day, with an interval of 1-2 Dna.poddererveshchaya dose for patients with a mass of more than 60 kg to 600 mg / day, below 60 kg to 400 mg. In patients with heart failure and liver and weighing more than 60 kilograms of supporting dose is 400 mg a day (can be up to 720 mg / day) less than 60 kg to 200 mg / day (possibly up to 480 mg / day) in 2 admission (morning and evening). Patients with rapid metabolism (smokers), and weighing more than 60 kilograms appoint 600 mg evening, and 300 mg morning; with a mass of less than 60 kg to 400 mg evening, and 200 mg morning. Children 6-8 years, 400-600 mg / day, 8-12 years, 800 mg / day, 12 to 18 years, 720-1080 mg / day (2 admission).

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