Cabergoline

Chemical name

1-[(6-Аллилэрголин-8бета -ил)карбонил]-1-[3-(димет иламино)пропил]-3-этил��очевина

Gross

C26-H37-N5-O2

Of drugs

The drugs - гипопролактинемическ ое. Prosecutor dofaminove D_2-retseptora glands and, like prolactostatino (dofaminu) reduces function and giperplaziu Lactotrofov.bystro drawn from the blood. C_max achieved through 0.5 hours Linking plasma protein-41-42%. Т_1/2 - 63-68 hrs healthy and 79-115 hour with пролактинемии. Excreted primarily Pockami.normalizuet the hormone in the blood, restores menstrual cycle and fertility. The level of prolactin in the plasma begins to decrease after 3 h, and remained so for 28 days. Returns pulsating секреция гонадотропинов and release source in mid-cycle, eliminated ановуляторные cycles and increased concentration estrogen in the body, the severity редуцируется гипоэстрогенных (increased body mass index, the delay fluid osteoporosis) and гиперандрогенных (skin, гирсутизм etc.) symptoms. Men reduces from гиперпролактинемией weakening Yeah, 04.07.2005 (with the declining levels of prolactin increased testosterone levels), гинекомастию, reduction and softening eggs, лакторею. Were opposite of pituitary macroadenoma and related symptoms (headache, the fields and the severity of view, the cerepnah nerves and the front of the pituitary). Lowers the hormone in patients with пролактиномой and псевдопролактиномой (at the last, without erosion of pituitary adenoma). Ingibiruet release sales pituitary adenoma and reduces visual impairment, neurological disorders and severe headaches, slowed the progression of akromegalia. The 70-90% of the patients was clinical improvement, but at the end of the loan in the blood once again mounting. Enlisting dofamine receptors neirohimicski restores balance in the striped body and black kernel brain, which has helped to reduce depressive symptoms, and tremora rigidnosti, accelerating movements at all stages of Parkinson's disease.

Indications

Prevention or suppression of lactation; Giperprolaktinemia (idiopathic when adenome glands), women (of menstrual function, infertility, galactorea, etc.) and men (the drive, impotence, etc.); Akromegalia (maintenance therapy after surgical or radiation treatment).

Restrictions on the use of

Arterial hypertension, ischemic heart disease and other serious diseases of the circulatory system, a disease Reynaud, saying disease stomach and duodenal ulcers, insufficient liver and kidneys, severe mental illness.

Contraindications

Гиперчувствительност ь (including from other derivative alkaloids LPV), postpartum psychosis (including in history), pregnancy, breast-feeding (with the ineffectiveness of repression after birth).

Side-Effects

Weak, ortostatical gipotenzia, nausea, dry mouth, constipation, zalojennosti nose, mouth his hands and legs with the impact of cold, allergic skin reactions.

Patient interaction

Macrolides increase concentration in plasma. 24.1 drugs, alcohol may alter the efficiency and portability.

Overdosing

Symptoms : headache, severe weakness, sweating, drowsiness, спутанность consciousness, agitation, hallucinations, гипотензия, convulsions in the gastrocnemius muscles, nausea, vomiting, stomachache, запор.Лечение : maintaining vital functions, in order to reduce exposure of the blood and central nervous system to the appointment метоклопрамида.

Precautions

The regular gynaecological examinations, dynamic monitoring of hormone levels in the serum (at least once a week) with the appropriate dose adjustment. A monitoring AD functions tract (potential risk of bleeding). If you have hypertension, constant headaches or any signs of neurotoxicity reception immediately cease. To reduce nausea should Opoczno dose appoint domperidon or cizaprid. If a woman does not plan to the birth of a child, before the course is to provide reliable contraception. After normalization of menstrual cycle for one month before the conception kabergolin overturned (as in the case of a pregnant at the time of treatment). During the first days of therapy requires increased caution when driving vehicles and working with machines and mechanisms. During treatment precluded admission of alcohol. Inefficiency каберголина suggests other factors гиперпролактинемии The lowering of ground hormone in the liver disease, chronic renal failure (especially in patients in гемодиализе).

Dosing and Administration

Inside, at the time of delivery, typically 0.5 mg 1-2 times a week. The maximum dose of 4.5 mg per week. To prevent post-lactation to 1 mg once on the first day after birth; To interrupt the usual weight on the 0.25 mg every 12 h for 2 days.

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