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Dostinex

See also Cabergoline

Roman name

Dostinex

Pharmacokinetics

After intake of rapidly absorbed from the digestive tract, C_max through 0.5 hours Away does not affect the induction and distribution. Linking plasma protein-41-42%. Provided with urine. T_1/2-p 63-68 healthy volunteers and 79-115 h in patients giperprolaktinemiei.

Farmakodinamika

Has expressed and long prolaktinsnijatim effect at higher doses is central dofaminergicescuu activity. Reduce prolactin plasma is after 3 h is 7-28 days in patients with giperprolaktinemiei (or healthy volunteers) and up to 14-21 days for women with postnatal lactaciei.

Indications

Prevention or suppression of the post-lactation (contraindications for breastfeeding, stillbirth, abortion, refusal to nurse); Treatment-giperprolaktinemia, with the human menstrual cycle (amenorea, oligomenorea, anovulyatsia), infertility) and galactoreei (women), impotenziei and reduced libido (men); пролактинсекретирующ ая pituitary adenoma (micro and macroprolaktinoma).

Pregnancy and lactation

Contraindicated in pregnancy (especially when dysgravidism). Before treatment should be deleted pregnancy and the subsequent use of barrier methods of contraception. In establishing pregnant at the time of receiving treatment drug terminated, and require immediate medical advice. After the restoration of the regular menstrual cycle that the treatment a month before the alleged conception (to prevent possible impact on the fruit as long T_1/2). In the absence of a contribution in the case of applications for the suppression of the post-lactation to refrain from breast-feeding to consult with a physician.

Contraindications

Гиперчувствительност ь (including the alkaloids LPV), liver failure, post-partum psychosis (including in history), the admission antipsihoticeskih drugs.

Specific guidance

In long-term care needs regular gynaecological examinations, including histological analyses (cervical, endometrium).

Patient interaction

Antiemetic and psychotropic substances, antibiotics, the macrolides (erythromycin, etc.) change the efficiency and portability.

Precautions

Observe caution when driving, working with machinery or other activities requiring attention. Be wary appointed to cardiovascular diseases, rheumatoid Reynaud, kidney failure, ulcers stomach and duodenal ulcer, gastric artistic methods, severe mental illness (including in history), in the face of gipotenziveh funds (because of the possible development of hypotension), macrolides and antiemetics drugs.

Storage conditions

List B. The temperature is not above 25 ° C

Shelf life

2

The registration

013905/01-2002

The drug forms

White Plane pills in the form of capsules. One tablet surface marked the letter "P" on one side and nasecki letter 'U' on the other; Another surface pills marked with "700" short naseckami top and bottom numbers.

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