Levodopa

Chemical name

3-gidroksi-l-tirosin

Gross

C9-H11-N04

Characteristics

The white crystalline powder. It is soluble in water, nerastvorim in alcohol.

Of drugs

The drugs - противопаркинсоничес кое. Is something predecessor. Penetrates the GEB, accumulate in bazalnah gangliah to become dofamin, offsetting weakness in the last ekstrapiramidna system. As a result, reduced muscle rigidity and hypokinesia. It absorbed by ingestion; C_max defined in 1-2 hours, some already in the blood transformed into dofamin and out of the bazale kernel (dofamin goes GEB). Write mainly kidneys.

Indications

Parkinson's disease, symptomatic parkinsonism.

Restrictions on the use of

Pregnancy, the age of child (up to 12 years), myocardial infarction in history. During treatment nursing mothers should suspend breastfeeding.

Contraindications

Expressed arteriosclerosis, hypertension, diseases of the liver, kidneys, blood, glaucoma, melanoma, bronchial asthma, mental illness, nekompensirovannaya cardiovascular disease, respiratory and endocrine systems.

Side-Effects

Horeoatetoidnye giperkineza, adults, and psychotic or paranoid reactions, diarrhoea phenomenon ulzeration stomach, headache, dizziness, visual impairment, haemolytic anaemia, and agranulozitos lakopenia, alopecia, allergic reactions.

Patient interaction

Effect diminishes vitamin B_6. Do the MAO inhibitors.

Dosing and Administration

Initial dose of 0.25 g / sut. After every 2-3 days dose increased by 0.25 g to daily-3 and higher daily intake - 6 and

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