Piribedil

Chemical name

2-[4-(1,3-Бензодиоксол-5-и��метил)-1-пиперазинил]п иримидин (and in the form of monometanculfonata)

Gross

C16-H18-N4-O2

Of drugs

The drugs - противопаркинсоничес кое. Is dofamine adrenergic receptors. Dofaminove stimulates receptors in the central nervous system, mainly in the nuclei ekstrapiramidna system. Increases blood brain tissue consumption of oxygen improves brain metabolism. Does the transfer of nerve impulses, increases the electrical activity of neurons crust (both during wakefulness as well as during sleep). Bring peripheral dofaminove receptors in the smooth muscular pressure and has vazodilatirtee Actie.bystro absorbed from the digestive tract. C_max achieved through 1h linking a plasma protein low. Biotransformiroetsa body in the formation of two major metabolites. T_1/2 (two-phase) is 1,7-6,9 hours Report mostly kidneys (68% in the form of metabolites), and jelchew (25%).

Indications

Violation of cognitive functions and neirosensornyi deficit in the process of ageing; Parkinson's disease - monotherapy (with the forms, including tremor), or in combination with levodopa. "Peremejatayasa" limp (obliterirute artery disease); Ischemic symptoms of eye diseases.

Pregnancy and lactation

Contraindicated in pregnancy (adequate and well-controlled studies in the application during pregnancy should be held), and during lactation.

Contraindications

Hypersensitivity Arterial gipotenzia, collapse, myocardial infarction (acute phase), pregnancy, breast-feeding.

Side-Effects

Worry and stir; Ortostatical gipotenzia; Nausea, vomiting, flatulence.

Patient interaction

Dopamine antagonists, including neiroleptiki (fenotiazina, butirofenona, tioksantena) and metoclopramide, may reduce the effectiveness of (complementary).

Overdosing

Симптомы: рвота.Л