Quinagolide

Chemical name

{+}-N,N-Диэтил-N'-[(3R*,4aR*,10aS* )-1,2,3,4,4a,5,10,10a-октагидро -6-гидрокси- 1 -пропилбензо[g]хинолин -3-ил]сульфамид (and as hydrochloride)

Gross

C20-H33-N3-O3-S

Of drugs

The drugs - гипопролактинемическ ое. Prosecutor dofaminove D_2-retseptora and suppresses the secretion of prolactin. The ingestion quickly and adequately absorbed. However, due to the effects of a "through the liver bioavailability below expectations. Associated with the plasma protein by 90%. The distribution of about 100 litres. Biotransformiroetsa in the liver by desetilirovania education inactive metabolites. 95% dose excreted (mostly in the form of metabolites) kidney and intestinal. T_1/2, 11.5 h, in the face of balance-of-17 C.effect proportional to dose, but an increase of more than 50 µ g does not increase efficiency, (although prolong it). Clinically significant reduction in hormone occurs after 2 h after administration reaches its peak four to six hours and a 24-hour With long-term use may detain growth or help inwalucia pituitary adenoma.

Indications

Giperprolaktinemia (including the pituitary adenome) with galactoreei, reduced sexual desire, or oligo- amenoreei, infertility.

Contraindications

Hypersensitivity, mental illness, breastfeeding (end secretia milk).

Side-Effects

Headache, dizziness, drowsiness, severe depression, anorexia, nausea, vomiting, pain in the abdomen, diarrhoea or constipation, hypotension ortostatical, zalojennosti nose.

Overdosing

Symptoms : nausea, vomiting, headache, dizziness, drowsiness, arterial hypotension, Galloucination.lechenie : symptomatic with feces and hallucinations appoint metoclopramide.

Precautions

During the first days of shows regular monitoring AD (ortostatical possible hypotension). If you have nausea and vomiting for 1 h to take hinagolida blokator dofaminergicakih peripheral receptors. Women of childbearing age who do not wish to become pregnant during treatment should be used reliable methods of contraception. In the case of pregnancy is possible lifting of the preparation. Prudence required in the application in patients whose work demands focus.

Dosing and Administration

Inside, the initial dose of 25 g / day for 3 days, in the next three days, 50 µ g / day, 7 days - 75 µ g / sut. The third patient, there is a need to increase the average daily dose of 300 micrograms. In such cases the dosage gradually increase every four weeks at 75-150 micrograms.

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