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Segan

See also Selegiline

Roman name

Segan

The composition and the form of

1 tablet contains selegilina hydrochloride 5 mg; in a contour acheikova packing 20 pcs. , in a cardboard 3 bundle packaging.

Of drugs

Противопаркинсоничес кое. Ingibiruet MAO-B, increases the release of catecholamines and in the brain, including in ekstrapiramidna system.

Pharmacokinetics

Rapidly absorbed from the digestive tract. C_max 2.2 ± 0.9 ng / ml achieved through 0.5-2 hours Selegilin and its metabolites are going through GEB in tissue and body fluids. Metabolised by zitohroma P450. Major metabolites - L-metamfenamin, L-amfenamin and N-demetilseligilin. T_1/2-26 ± 11 hrs Return with urine in the form of L-metamfenamina (2702%), L-amfenamina (9-26%), N-demetilselegilina (1%) and faeces (15% within 72 h).

Indications

Parkinson's disease (mono or combination therapy), dementia alzgeimerovsky type (complex therapy).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, ekstrapiramidnye disorders, psychosis, arterial hypertension, severe pain, irregular, endocrine disorders (feohromotsytoma, diffuse toxic goitre), zakratougolnaya glaucoma, a disease hospital of stomach and duodenal ulcers, prostate adenoma cancer, dementia, Medicine unknown etiology, simultaneous antidepressants and up to five weeks after the repeal, pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : headache, dizziness, drowsiness / insomnia, anxiety, hallucinations, sputannosti consciousness, psychosis, diskinesia / bradikinesia, impaired memory, confusion, depression, reduced libido, noise in the head, a violation Zrenia.so the circulatory system and blood (blood, gemostaz) : heart, ortostatical gipotenzia, Aritmia.so part of the intestine : anorexia, dry mouth, nausea, constipation / Diarea.prochie : lower body mass index, the delay urination, sexual dysfunction, skin rashes, shortness of breath, increased liver transaminaz.

Patient interaction

Enhance and prolong the effect of levodopa, amantadina, antiholinergicakih of catecholamine, alcohol. Tricyclic antidepressants potenziruut side effects.

Overdosing

Symptoms : dizziness, headache, agitation, convulsions, the rhythm of the heart, arterial hypertension, hyperthermia, excessive sweating, oppression Dahania.lechenie : induction vomiting, stomach wash, the use of activated carbon; In initiating and fits in / with the introduction of diazepam; Symptomatic therapy.

Precautions

If any of the liver or kidney to lower doses. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. It should refrain from the use of drugs in paediatric practice (safety and efficiency to be determined).

Dosing and Administration

Inside, at the time of delivery, when alone : to 5 mg twice a day; In combination therapy with levodopa initial dose, 10 mg one or two times a day (morning and afternoon), then in 2-3 days levodopa dose reduced by 10-30%.

Storage conditions

table. : List B. In dry the dark place at a temperature of no higher than 25 ° C

Shelf life

table. : 3 and

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