Albarel

Roman name

Albarel #

The composition and the form of

1 tablet contains rilmenidine 1 mg; blistere in 10 pcs. , in box 1, 2 or 3 blisters.

Of drugs

Antihypertensive. Selectively interacts with the receptor imidazolinovmi (I_1) brain and peripheral vazomotornah structures and kidney ingibiruet simpatomimeticescuu activity. Decreases reabsorbqiyu sodium and water in the proximal renal bone. Lowers AD by reducing round.

Pharmacokinetics

Quickly and completely absorbed from the digestive tract. Absolute bioavailability 100%. C_max (3.5 ng / ml) in the plasma is in 1.5-2 hours Associated with the plasma protein by 10%. Weak metabolised, displayed in the main memory (65% in unmodified form). Kidney Cl 2 / 3 total Cl. T_1/2-8 pm

Clinical pharmacology

Antigipertenzivny effect maintained for a period of 24 hours In therapeutic doses does not affect the function of the heart, there is a delay of sodium and water in the body, orthostatic phenomena, including in older people does not affect renal blood, clubockovu filtering or filtration fraction of carbohydrate and fat metabolism, incl. in patients with diabetes I and II types.

Indications

Arterial hypertension.

Pregnancy and lactation

Not recommended during pregnancy and during breast-feeding, because sufficient clinical data are not available.

Contraindications

Hypersensitivity, severe depression expressed by the lack of kidney function (Cl creatinine less than 15 ml / min in the absence of the kidney).

Side-Effects

From the nervous system and sensory organs : fatigue, insomnia, drowsiness, fatigue increased in the physical work, a sense of fear, Deprescia.so the circulatory system and blood (blood, gemostaz) : heart, ortostatical gipotenzia, Priliv.so part of the intestine : pain in epigastralna area, dry mouth, diarrhea or constipation, Toshnota.prochie : skin rashes, very rarely passed limbs, skin and peripheral edema.

Patient interaction

Incompatible with MAO inhibitors. Tricyclic antidepressants reduce antigipertenzivny effect.

Overdosing

Symptoms : expressed arterial gipotenzia, mental Narushenia.lechenie : washing stomach, a simpatomimeticakih funds. Haemodialysis ineffective.

Precautions

Cancel the drug is gradually. Patients who had undergone recent stroke or heart attack, should be under constant medical supervision. Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention. During treatment is not recommended to consume alcohol. When kidney failure if Cl creatinine more than 15 ml / min dose adjustment is not required.

Dosing and Administration

Inside, and 1 mg once a day (morning). The lack of efficiency through 1 month dose can be increased to 2 mg / day in 2 admission (morning and evening during mealtimes). Treatment long.

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