Acrivastine

Chemical name

(E,E)-3-[6-[1-(4-Метилфенил)-3 -(1-пирролидинил)-1-проп енил]-2-пиридинил]-2- propenova acid

Gross

C22-H24-N2-O2

Characteristics

Derived pirrodinilpiridinov. The white crystalline powder, odourless. Rat in chloroform and alcohol, little soluble in water.

Of drugs

The drugs-antigistaminnoe, protiwallergicescoe, antiekssoudativoe. Does gistaminove H_1-retseptora reduces bodily reactions histamine, reduces the permeability of capillaries and exudation. Warn development and facilitates the allergic reactions. Ters symptoms of seasonal allergic rinita (cough, sneeze, itch, slezotechenie). Protiwallergiceski and antiekssoudativei effects being felt after 30 minutes, reach a peak in 1-2 h and continuing until 6 pm Provides weak holinoliticescoe and sedate Actie.v experimental studies have been found carcinogenic, mutagennogo effect and impact on the fans Fertilnosti.horosho (eating no effect on AUC). Linking plasma proteins (mostly with albuminom and to a small extent from alfa_1-kislam glikoproteinom) is 48-52%. T_max 0,8-1,7-hour C_max-227 + 47 ng / J The evenly distributed in the body, poorly crosses the GEB. The distribution in the one-time application is 0.46 ± 0.05 l / kg, in a position stable balance increased to 0.82 + 0.6 l / kg (at the same time increasing T_1/2). Slight metabolised education active metabolita (analogue Propionic acid), the concentration of which is down 10% in the preparation. T_1/2 akrivastina in final stage 1,4-2,2-p (for metabolita 2,4-5,2-p), Cl - 2.9 + 0.7 ml / min / kg 84% return with urine for 48 h (67% in unaltered, 11%, in the form of counterpart Propionic acid, 6% in the form of unidentified metabolites). In patients with chronic renal insufficiency in Cl creatinine 26-48 ml / min T_1/2 increased by 50%, with Cl creatinine 6-17 ml / min at 130%, and its metabolita at 140% and 400% respectively. Through dialysis removed 20% akrivastina and 27% metabolita. The ageing of the 44% below. There are significant differences of pharmacokinetics in patients of different ages, sex and race.

Indications

Allergic rhinitis, pollinoz, allergic Medicine, zudahaya atopica eczema, symptomatic dermografizm, urticaria (chronic idiopathic, holinergical, cold).

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь (incl. to triprolidinu) expressed kidney failure, pregnancy, breast-feeding, child age (up to 12 years).

Side-Effects

From the nervous system and sensory organs : seldom-headache, dizziness, nervousness, insomnia, drowsiness, reduced speed of mental and motor reactions of внимания.Аллергическ��е reactions : very rarely, anaphylaxis, angioneuroticeski swelling, bronhospazm, mnogoformnaya Eritema.so part of the intestine : seldom-dry mouth, nausea, Dispepcia.prochie : pharyngitis, dismenorea.

Patient interaction

Alcohol and other means, depressing the central nervous system and it may reinforce impact on the central nervous system (combination is not recommended).

Overdosing

Symptoms : weakness, paleness, insomnia, drowsiness, fear, anxiety, arousal, tremor, convulsions, dizuria, incredible, Kollaps.lechenie : symptomatic and supportive therapy.

Precautions

Be wary of during the drivers of vehicles and people skills relate to the high concentration of attention. An older patients to control functions of the kidneys.

Dosing and Administration

Inside, adults and children over 12 years of age-to 8 mg three times a day.

Literature

J. Slater, D. Zechnich, Haxby D. Second-antihistamines. A comparative review / / Drugs - 1999 .- V. 57-N-1 P. 31-47.

Directory → Интермедианты → Gistaminergicakie funds → Gistaminolitiki → H_1-antigistaminne funds → Acrivastine