Chloropyramine

Chemical name

N-[(4-Хлорфенил)метил]-N', N'-диметил-N-2-пиридинил -1,2-этандиамин (and as hydrochloride)

Gross

C16-H20-Cl-N3

Characteristics

Derived etilendiamina.

Of drugs

The drugs-protiwallergicescoe, antigistaminnoe, holinoliticescoe, sedative, sleeping, skin. Does gistaminove H_1-retseptora and m-holinoretseptora. Ters spazmogennoe gistamina effect on smooth muscles bronchi and intestines, reduces its gipotenzivny effect and influence on the permeability of the receptacles. Warn development and facilitates the allergic reactions immediate type. Provides protivozudnoe, sedative and sleeping effect. And moderate peripheral holinoliticaskoy and spazmoliticescoy Aguostew.pri ingestion completely and rapidly absorbed. The concentration in the blood reaches a peak within 2 hours and maintained at therapeutic level for the 4-6 hours Evenly distributed in the body, crosses the GEB. Metabolised in the liver, kidneys displayed and gastrointestinal.

Indications

Allergic disease (urticaria, rhinitis, conjunctivitis, pollinoz, angioneuroticeski swelling, savorotocnaya disease), drug allergies, skin diseases (eczema, contact dermatitis, neirodermit, skin itch, toxicodermia), the initial stage of asthma light water (composed of combination therapy), acute respiratory infections and intestinal infections in children (in conjunction with jaroponijatmi means).

Restrictions on the use of

Increasing erosivno-yazvennah tract diseases, the delay urination.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, incl. from other derivative etilendiamina, zakratougolnaya glaucoma, prostate adenoma with cancer expressed violation urodynamics, pregnancy, breast-feeding, early breast age (up to 1 month).

Side-Effects

From the nervous system and sensory organs : lethargy, weakness, psychomotor slowing reactions, drowsiness, dizziness, the coordination Dwijeni.so part of the intestine : dry mouth, nausea, gastrointestinal disorders; Rarely gastralgia.

Patient interaction

Funds zashchelacivate urine increase, and zakislate-weakened therapeutic and side effects. Increases risk of convulsing against analeptikov. Do the narcotic analgesics, general and local anaesthetics and abused sedatives, ethanol. Tricyclic antidepressants contributed to m-holinoliticakih effects and oppressive action on the central nervous system. Barbiturates can accelerate the metabolism and reduce the effects. Phosphabenzide effect on the central nervous system decreases caffeine and fenaminom rise-clofelinom.

Overdosing

Symptoms : adults-block, depression, the sense of violation, up to the coma, possible agitation, convulsions, rarely hyperemia, hyperthermia. The children midriaz, hyperemia and hyperthermia, anxiety, arousal, hallucinations, ataxy, atetoz, convulsions, collapse, Koma.lechenie : washing stomach, the appointment of activated carbon plant laxatives, the maintenance of heart and respiratory system, as appropriate, protivosudorojnaya therapy IVL.

Precautions

For acute and allergic reactions anaphylacticakih treatment start with the / in the introduction, then move on to the / m. In the application of the children, a strict medical control (perhaps a heightened sensitivity). During the initial period of therapy from driving vehicles and undertaking requiring quick mental and motor reaction. It is not to drink alcohol at the time of treatment.

Dosing and Administration

Inside, at the time of delivery, in the / m and / 386/1989 Adults : 25 mg three times a day (up to 150 mg / day); In / m, / with 1-2 mL of 2% solution. Children : 2-3 times a day, 12 months to 6.25 mg, 1-6 years, 8.33 mg, 7-14 years 12.5 mg.

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