Clemastine

Chemical name

[R-(R*,R*)]-2-[2-[1-(4-Хлорфени��)-1-фенилэтокси]этил]-1- метилпирролидин (in the form of fumarata)

Gross

C21-H26-Cl-N-O

Characteristics

Derived etanolamina. crystalline powder, colourless or slightly yellow, almost odourless.

Of drugs

The drugs-antigistaminnoe, protiwallergicescoe, protivozudnoe, antiekssoudativoe. Does gistaminove H_1-retseptora. Warn vazodilatace development and the reduction of smooth muscles induced gistaminom. Decreases capillary permeability, inhibits exudation and the development of inflammation, reduces itching. Holinoretseptora block in the CNS and peripheral tissues, is a moderate sedative effect is mestnoanestezirutuyu Aguosti.soglasno The pilot studies is not carcinogenic, and mutagennogo tertogennogo action. At dose, in the 312 times the recommended therapeutic dose for adults is adversely affecting fertility Kras.posle intake of rats almost completely. C_max in plasma achieved over a period of two to four hours, the maximum effect develops in 5-7 hours Linking blood plasma is 90-95%. Passes through GEB will seep into the breast milk. Metabolised in the liver. Place in two phases : T_1/2 first phase of 3.6 ± 0.9 h, the second 37 + 4.30 Excreted in the urine, mostly in the form of metabolites (45-65%). The duration of the 8-12 hour (in some cases up to 24 hours).

Indications

To be accepted into : urticaria, savorotocnaya disease bloody vasculit, rhinitis (allergic, vazomotornyi) pollinoz, skin itch, zudaschie Medicine, contact dermatitis, eczema (acute, chronic), acute iridotsyklit, drug exantema, allergic reactions caused by bites Nasekomah.dl liver Use : angioneuroticeski swelling, or anaphylactic shock anaphylactoidnyi (complex therapy), the prevention of allergies and psevdoallergicakih of (application rentgencontrastnykh funds blood transfusions, the introduction gistamina).

Restrictions on the use of

Zakratougolnaya glaucoma, stenozirutaya stomach ulcers, obstructive phenomenon in piloricescom and duodenal stomach divisions or in the neck, bladder, prostate hypertrophy cancer, involving violations of urination.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, child up to 1 year (syrup), or up to 6 years (pills), pregnancy, breast-feeding.

Side-Effects

From the nervous system and sensory organs : sedative effect weakness, a sense of fatigue, block, headache, dizziness, drowsiness, and the coordination of movements, rarely stimulate (usually the children) : anxiety, irritability, arousal, nervousness, insomnia, hysteria, euphoria, tremor, convulsions; Paresthesia, rapid, the fog, diplopia, acute labirintit, noise Ushah.so part of the intestine : nausea, dry mouth, jeludochny discomfort, rarely pain in epigastria, constipation and, in individual cases, anorexia, vomiting, Diarea.so the respiratory system : temperature Bronchus secret and inhibiting othozdenia positive, a sense of pressure in the chest, breathing problems, zalojennosti Nos.so the circulatory system : gipotenzia (more commonly in the elderly), palpitations, tachycardia, arrythmia; Hemolytic anemia, thrombocytopenia, Agranulozitoz.so the urogenital system : very rarely makes the urine, urine retention, frequency of urination, changing menstrual �ункции.Аллергические �ection : very rarely urticaria, skin rashes, and in / in the introduction-smoking, bronhospazm, anaphylactic Shok.prochie : photosensitization.

Specific guidance

It must not be possible in / and the introduction. Ampulny solution contains ethanol. To prevent distortion of the skin skarifikih samples for allergens, medication should be lifted for 72 hours before allergologicaki testing.

Patient interaction

Potenziruet the doses, alcohol, sedatives, hypnotics, anaesthesia and other products oppressive central nervous system, the effect holinoblokatorov. Incompatible with MAO inhibitors (lengthened and strengthened holinoliticescoe effect).

Overdosing

Symptoms : Children-midriaz, lack of inhibition reaction to light, dry mouth, reddening of fever, zianoz, causing hallucinations, the coordination of movements, ataxy, atetoz, tremor, giperreflexia, tonico-clauniceskie convulsions, depression, oppression heart and respiration (possible death). The adult CNS oppression, drowsiness, collapse, convulsions, Koma.lechenie : Noon vomiting, a salt laxatives (to the inside); Symptomatic and supportive therapy : Fever in children can be used obtiranie cooling, in the case of hypotension, a sossoudossoujiwath preparations for cupping convulsing, or diazepam korotkoactute barbiturates, if necessary fizostigmin, IVL; monitoring vital functions.

Precautions

Be wary appoint patients gipertireozom and cardiovascular disease, including arterial hypertension. During treatment should abandon alcohol. Careful observation of the children and patients older (enhanced sensitivity to antigistaminnam drugs). At the beginning of the treatment should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention; Thereafter to the degree of restriction of the individual drug tolerance.

Dosing and Administration

Inside (before delivery) adults and children after 12 years, 1 mg (tablets), or 20 ml (1.5 art. Spoon syrup) twice a day (morning and evening), as appropriate to 6 mg or 120 ml of syrup per day; Children aged 6-12 years, 0.5-1 mg twice a day. Syrup : children 1-3 years c.logki 1-2, 4-6 years in the two c.logki, 7-12-1 st.lojku. Dropped : adult / in the (slow) or / m 2 mg twice a day to children in / m in the dose of 25 µ g / kg / day of 2 admission.

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