Desloratadine

Chemical name

8-хлор-6,11-дигидро-11-(4-п��перидинилиден)-5H-бенз о[5,6]циклогепта[1,2-b]пир идин

Gross

C19-H19-Cl-N2

Of drugs

The drugs-antigistaminnoe, protiwallergicescoe, противовоспалительно е. Yes blocks peripheral gistaminove N_1-retseptora. Suppress cascade cytotoxic reactions : the provospalitionah Cytokines, incl. interleikina-4 (Test 4), interleikina-6 (YL-6), interleikina-8 (SILT-8), interleikina-13 (YL-13), type hemokinov RANTES, products superoxidnyi anion activated polimorfnoyadernami neitrofilami, adhesion and chemotaxis Eosinophils, expression of adhesion molecules, including R-selektina, Ige-zawisimoe the gistamina, PGD_2 and Lts_4.ejednevnoe use in the dose to 20 mg for 14 days has not been accompanied by significant (statistical or clinical) changes of the cardiovascular system. In 10-dnevnom use dose of 45 mg / day (nine times the therapeutic) is not longer QT interval. The dose of 7.5 mg is not accompanied by violations of psychomotor functions, and, in the dose of 5 mg, increasing the frequency sleepiness, compared with a group of Platzebo.issledovania on animals have shown the ability to remove desloratadina severe allergic бронхоспазм.Биодосту��ность proportional to the dose (in the range of 5 to 20 mg). Dezloratadin is determined plasma within 30 min after administration. Time to C_max plasma after a single reception 5, or 7.5 mg 2-6 hours (average three hours). Associated with the plasma protein to 83-87%. T_1/2 - 20-30 hours (average 27 hours). It passes through GEB, crosses the placental barrier, and in breast milk. Extensive metabolised by gidrauxilirovania education and 3-on-dezloratadina glukuronirovania. Return with urine (less than 2% in unmodified form) and faeces (less than 7% of the unmodified form). When taken doses of 5-20 mg / day for 2 weeks cumulation is not observed.

Indications

Seasonal allergic rhinitis (mild symptoms : sneeze, rinorea, zalojennosti nose, itching in the nasal cavity and the sky, cough, itching and red eyes, slezotechenie).

Restrictions on the use of

Children's age (safety and efficacy of the children are not identified).

Pregnancy and lactation

Contraindicated in pregnancy (security is not determined). At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Side-Effects

Headache (2%), fatigue (1%), dry mouth (> 0.1%).

Overdosing

Symptoms : Symptoms increased by Reackzi.lechenie : symptomatic therapy. Haemodialysis ineffective.

Precautions

With the caution expressed in kidney failure.

Dosing and Administration

Inside, regardless of the meal, not liquid, water teenagers, adults and adolescents aged 12 and over, 5 mg / sut.

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