Dimenhydrinate

Chemical name

2-(Дифенилметокси)-N,N-д��метилэтанамина complex with 8-hlortheofillinom

Gross

C24-H28-Cl-N5-O3

Of drugs

The drugs-antigistaminnoe, holinoliticescoe, protivorvotnoe. Does gistaminove H_1-retseptora and m-holinoretseptora CNS. Giperstimulirovannuu oppressing the maze. Provides protivorvotnoe, protivotoshnotnoe, sedative, moderate protiwallergicescoe act eliminates dizziness. Step is a 20 to 30 minutes and lasts for 4-6 C.v screening tests for mutagenicity, there have been positive results in studies on bacterial systems, and negative-in the use of tissues and cells Mlecopitath.posle intake of a well-absorbed, distributed to organs and tissues, fully displays the kidneys within 24 hours Small quantities excretiruyutza with breast milk.

Indications

The sea and air sickness, Ménière disease, prevention and treatment of nausea and vomiting (with the exception of anticancer chemotherapy).

Restrictions on the use of

Be wary appointed to the isolationist prostate, uzkougolna glaucome, gipertireoze, cardiovascular diseases, bronchial asthma, stenoziruta pepticescoy anthrax, piloroduodenalna obstruction or obstruction neck bladder, breast-feeding.

Pregnancy and lactation

Contraindicated (I-trimester screening), or possibly with the utmost care (II term), if the effect of therapy outweighs the potential risk to the fetus. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, epilepsy, acute and ekssoudativee vezikuliarnae Medicine, pregnancy (I trimester), children's age (up to 2 years).

Side-Effects

From the nervous system : weakness, fatigue, the concentration, headache, dizziness, anxiety, nervousness, drowsiness, insomnia (especially in children), rarely weakening night and color of violation Ccomodation.so part of the intestine : dry mucous membranes of the oral cavity, reduced appetite, nausea, vomiting, epigastralny Distress.so the respiratory system : dry mucous membranes nose and throat, temperature Bronchus Secreta.so the circulatory system and blood : gipotenzia, tachycardia, Hemolytic Anemia.allergicakie reactions : skin rash, rarely medikamentosny Dermatit.prochie : development of Drug Dependence (with the long-term use), rarely dizuria.

Patient interaction

Do effects of atropine, tricyclic antidepressants, catecholamines, barbiturates, alcohol, sedatives and tranquilizers funds doses weakens, Corticosteroids, anti. Reduces reaction to apomorfin. Decreases depressive effect acetylcholine in the heart muscle. Combination therapy with bismuth, skopolaminom, obezbolivatmi and psychotropic substances increases the likelihood of visual impairment. Incompatible with ototoksicskimi antibiotics (streptomycin, neomycin, viomitin, amikacin, kanamycin), as can mask symptoms ototoksicnosti and contribute to the development of irreversible hearing impairment.

Overdosing

Symptoms : fatigue, drowsiness, headache, dizziness, skin and the pressure of skin, midriaz deceleration pupillary reaction to light, the ccomodation, movement, demotion tone muscles and reflexes sukhojilnykh, urine retention, tachycardia, changing blood pressure. The exhibit symptoms of central nervous system of oppression (the speech, orientation in time and space, ataxy), coma, respiratory depression may bring forth; Children, hallucinations, convulsions, death Ishod.lechenie : washing stomach suspension activated carbon (20-30 grams), and the appointment of salt slabitelnogo (10-15 g of sodium sulfate), IVL, oxygen. The convulsions in children, phenobarbital (05-06 mg / kg), diazepam.

Precautions

During the initial period of therapy from driving vehicles and undertaking requiring quick mental and motor reaction. Be wary assign to old age.

Dosing and Administration

Inside (the food), with the 0.5 hours before anaesthesia, emergency motion, the admission poorly carried drugs : adults and children older than 14 years, 50 mg, for children from 2 to 6 years, 50 mg, between 7 and 14 years, 50 mg, if necessary Powthorno.pri feces and nausea : adults, 50-100 mg, as necessary every four hours, but no more than 400 mg per day, children 2-6 years 12,5-25 mg every 6 to 8 hours (no more than 75 mg per day), children between 6 and 14 years of age, 25 to 50 mg three to four times a day with a maximum daily dose is 150 mg.

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