Dimetindene

Chemical name

N,N-Диметил-3-[1-(2-пириди��ил)этил]-1H-инден-2-этан амин (as maleate)

Gross

C20-H24-N2

Characteristics

Derived alkilamina. The white crystalline powder and odourless, gorkovatogo taste. It is soluble in water and alcohol.

Of drugs

The drugs-antigistaminnoe, protiwallergicescoe, protivozudnoe. Does H_1-gistaminove receptors has antibradikininovoe, weak m-holinoliticescoe and sedative effect. Impact on the severity of allergic reaction, reduces the permeability of capillaries, skin, etc. prevents the allergic reactions of the immediate and growing due to the release of new servings Gistamina.bystro and almost completely absorbed by ingestion. Treated presistemna off in the liver bioavailability is about 70%, tying with the plasma protein-90%. Once inside C_max in a cell for 2 hours It penetrates the tissues, passes through GEB. In nakojna software bioavailability was 10%. Partly biotransformiroetsa in the liver, and presented, including in the form of active metabolites in the urine and jelchew. T_1/2 of 6900 (solution) and 11 h (prolongirovannaya form). Once inside the development within 30 minutes and lasts from 8 to 12 p.m.

Indications

Inside-ranging exposed skin (except itching to holetaze), urticaria, eczema, allergodermatozy, pollinoz, allergic rhinitis, angioneuroticeski swelling, food and drug allergy, allergic reactions to specific giposencibilization (treatment and prevention), with exantema Infectious Diseases (rubella, measles, chickenpox); Anaphylactic shock and savorotocnaya disease (aid). External - zudaschie Medicine, urticaria, allergic reaction to insect bites, burns to light (sun, household).

Restrictions on the use of

Zakratougolnaya glaucoma, neck obstruction bladder, prostate adenoma cancer, the exacerbation of asthma, pregnancy (trimenon II), breast-feeding a young child (up to one year).

Pregnancy and lactation

Contraindicated in the first trimester of pregnancy, in the neonatal trimestrah possible only by strict conditions, if the effect of therapy outweighs the potential risk to the fetus. Avoid the use of the gel in the first trimester of pregnancy and in neonatal trimestrah-causing vast surface of the body (especially when ekssoudativeh and inflammatory processes). During breastfeeding is not recommended to appoint inwards and cause of a lot of skin and nipples area (if the need should stop breastfeeding).

Contraindications

Hypersensitivity, incl. from other derivative alkilamina neonatal period (especially low), pregnancy (I term).

Side-Effects

From the nervous system and sensory organs : fatigue, weakness, drowsiness (especially at the beginning of treatment), dizziness, rarely headache, initiation (especially in infants), random night (children under age 1). For part of the intestine : dry mouth and throat, nausea, vomiting, rarely about stomach pains, worsening ulcers stomach and duodenum Kishki.allergicakie reactions : rarely allergic skin Reaktion.prochie : rarely causes problems, skin rashes, muscle spasm, in a few cases, violations on the part of the respiratory tract, sdavljenia feeling in the chest; in the use of the gel : rarely taste and stinging sensation at the site of.

Specific guidance

When distributed defeat skin possibly combining local treatment in the reception inside.

Patient interaction

Do dampening effect on the central nervous system tranquilizers, sleeping and alcohol m-holinoliticaskie effects antiholinergicakih and tricyclic antidepressants (increases the risk of vnutriglaznogo pressure).

Overdosing

Symptoms : CNS oppression, drowsiness (mostly adults), the initiation of CNS, ataxy, hallucinations, convulsions tonico-clauniceskie, midriaz, dry mouth, tides blood to a person whose urine and fever (especially in children); Gipotenzia, Kollaps.lechenie : appointment of activated carbon, salt slabitelnogo, symptomatic therapy for the maintenance of the cardiovascular and respiratory systems (analepticalkie funds are not recommended).

Precautions

It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of Vnimania.posle gel should be avoided altogether coated skin. In paediatric practice is not recommended without gel vast surface of the skin (especially when ekssoudativeh and inflammatory processes).

Dosing and Administration

Inside (preferably before meals) adults on 20-40 ml syrup 3 times daily or 40 mg (1 caps.) Once a day (at night); Single dose children from 2 months to 1 year to 10 drops, from 1 to 3 years, 10 to 15 drops, over three years in the 15 to 25 drops of a four times daily; treatment duration should not exceed three months. External, gel are thin in plot hit 2-4 times a day.

Literature

Kyrein Jr., F. Horak, Nirnberger G., D. Rehn Efficacy of applied intranasally dimethindene maleate solution as spray in adult volunteers with symptoms of seasonal allergic rhinitis in the vienna challenge chamber / / Arzneim.-Forsch .- 1996 .- V. 46-N 8 .- P. 794-799.

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