Ebastine

Chemical name

1-[4-(1,1-Диметилэтил)фен��л]-4-[4-(дифенилметокси) -1-пиперидинил]-1-бутан��н

Gross

C32-H39-N-O2

Of drugs

The drugs-antigistaminnoe, противоаллергическое . Does gistaminove H_1-retseptora. Warn caused gistaminom cramps smooth muscles and increase vascular permeability. Activity begins in one hour and lasts 48 hours. After five of antigistaminny effect maintained for a period of 72 hours, through the active metabolita. There has been impact on QT interval ECG (in doses up to 80 mg). Quickly absorbed and almost completely metabolized in the liver to active metabolita - karebastina. After one reception in ebastina dose of 10 mg C_max karebastina (80-100 ng / ml) is achieved through 2.6-4 hours Simultaneous eating increases karebastina in blood GHz times, but does not alter the time C_max and severity of clinical effect. Equilibrium concentration (160 ng / ml) with a daily dose of admission 10 mg via a 3 - 5 days. Linking blood plasma and ebastina karebastina more than 95%. T_1/2 karebastina - 15-19 h. Return with urine in the form of kongugatov (66%). It permeates through Geb.znacenia farmakokineticeskih parameters do not depend on the age of the patient. Against the backdrop of kidney failure T_1/2 rises to 23-26 hours, liver, and 27 hours

Indications

Allergic rhinitis (seasonal, year-round), chronic idiopathic urticaria.

Restrictions on the use of

Age to 12 (safety and efficacy of the application of non-identified).

Pregnancy and lactation

Not recommended (safety of the pregnant and lactating women is not known).

Contraindications

Гиперчувствительност ь.

Side-Effects

Headache, drowsiness, dry mouth; Rarely pain in the abdomen, neuralgia, nausea, fatigue, insomnia, rhinitis, sinusit.

Patient interaction

Not recommended simultaneous application with ketokonazolom and eritromitinom (possibly extending QT interval). Compatible with theofillinom indirect antikoagulyantami, zimetidine, diazepam, ethanol, etanolsoderjasimi drugs.

Overdosing

Treatment : washing stomach, monitoring vital functions, symptomatic therapy.

Precautions

The caution should be used in patients with kidney or liver failure.

Dosing and Administration

Inside, regardless of the meal. Adults with allergicescom rinite - 10-20 mg once a day (depending on the extent syndrome), and chronic idiopathic krapiwnice-10 mg once a day.

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