Erolin

Roman name

Erolin #

The composition and the form of

1 tablet contains loratadina 10 mg; in a contour acheikova packing 10 pcs. , in a carton 1, or 3 ml upakovki.1 syrup to 1 mg; Patients in the dark glass of 120 ml, with the dipping a spoon in the box one bottle.

Of drugs

Antigistaminnoe, protiwallergicescoe, antiekssoudativoe, protivozudnoe. Selectively blocking H_1-gistaminove receptors and prevents the gistamina the smooth muscles and blood vessels, reduces the permeability of capillaries, slows exudation, reduces itching and erythemal.

Pharmacokinetics

After intake of rapidly absorbed from the digestive tract. C_max blood through a 1.3 hour active metabolita (дескарбоэтоксилорат��дина) through 2.5 hours The meal loratadina AUC and its active metabolita increasing, but slows the achievement C_max at 1 h (recommended the product to food). Linking protein is 97% (active metabolita 73-77%). Equilibrium concentration loratadina and its active metabolita plasma achieved by the 5th day. Biotransformiroetsa intensively in the liver of zitohroma R450 education metabolita active. Within 24 h 27% of the total dose to return with urine in the form of metabolites and / or kongugatov. After 10 days, about 80% of metabolites excretiruyutza equally with the urine (40%) and faeces (40%). T_1/2 loratadina 12-15 hours Passes through the placental barrier, enters the breast milk.

Farmakodinamika

Warn development and facilitates the allergic reactions. Effect develops after 1-3 hours, reaches a maximum at 8-12 h, and remained at least 24 hours

Indications

Allergic rhinitis (seasonal and year-round), allergic conjunctivitis, chronic idiopathic urticaria, zudaschie Medicine (contact allergodermatita, chronic eczema).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding, age up to 2 years.

Side-Effects

From the nervous system and sensory organs : headache, drowsiness, a sense of fatigue, anxiety, malaise, giperkinesia and conjunctivitis (children). For part of the intestine : increased appetite, dry mouth, nausea, vomiting, unpleasant feelings in the stomach, pain in Zivote.so the respiratory system : dizziness, disfonia.

Patient interaction

Erythromycin, ketokonazol, zimetidin increase the concentration loratadina and its active metabolita in blood. Lowers the level of erythromycin in the plasma (15%).

Overdosing

Symptoms : headache, drowsiness, Tahikardia.lechenie : induction vomiting syrup ipekakuana washed stomach, the appointment of activated carbon; Symptomatic and supportive therapy.

Storage conditions

syrup : List B. The temperature 2-25 ° Ctabl. : List B. The temperature of 15-25 ° C

Shelf life

syrup : 2 city. Opened feet-6 mes.tabl. : 3 and

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