Fenspiride

Chemical name

8-(2-Фенилэтил)-1-окса-3,8- диазаспиро[4,5]-декан-2-��н (as hydrochloride)

Gross

C15-H20-N2-O2

Of drugs

The drugs-antigistaminnoe, bronhodilatirtee, protiwastmaticescoe, противовоспалительно е. Does gistaminove H_1-retseptora is antagonist inflammation mediators (serotonin, gistamina, bradikinina) offers papaverinopodobnoe skin effect. In high doses reduces products provospalitionah Agents (Cytokines, necrosis factor alpha tumors, metabolites arahidonova acid free radicals), some of which have bronhosuerveschee effect. In experimental studies found the likelihood of tertogennogo effect (development volchei graze "). Well drawn from the blood, C_max achieved through 6900 (tablets), or 2.3 hrs (syrup); T_1/2-12 p.m. Write mainly kidneys (90%) and gastrointestinal (10%).

Indications

Rinofaringit, laringit, rinotraheobronhit, otitis, sinusit, chronic bronchitis with respiratory distress, bronhospasticski syndrome, bronchial asthma (maintenance therapy), respiratory irregularities in the measles, pertussis and influenza (syrup).

Restrictions on the use of

Pregnancy, breast-feeding.

Pregnancy and lactation

When pregnancy is possible if the expected effect of therapy outweighs the potential risk to the fetus. Is not recommended during breastfeeding.

Contraindications

Hypersensitivity, the children's age (for tablets).

Side-Effects

For part of the intestine : nausea, neuralgia, pain in Jeludke.so the nervous system : drowsiness, Vozbussion.so the circulatory system : seldom - тахикардия.Аллергиче��кие reactions : urticaria (due to the presence of the syrup �ара-гидроксибензоата ).

Overdosing

Symptoms : sleepiness or agitation nausea, vomiting, sinusova Tahikardia.lechenie : washing stomach, maintaining vital functions; A ECG monitoring.

Precautions

Sunset yellow S, which is part of the syrup as a colorant may provoke the allergic reactions, including bronchoconstriction (especially for people with a heightened sensitivity to aspirin).

Dosing and Administration

Inside. Adults to food : on February 1 st. spoons (15-30 ml) syrup 3 times daily or 80 mg (1 tab). 2-3 times a day. Children (in the form of syrup), weighing up to 10 kg, 2-4 c.logki syrup (10-20 ml) a day (can be added with little food), weighing more than 10 kg-st.logki 2-4 syrup (30-60 ml) daily, before meals.

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