Kestin

Roman name

Kestine #

The composition and the form of

1 tablet coated liner ebastina contains 10 mg; blistere in 10 pcs. , in a carton one blister.

Of drugs

Противоаллергическое . And troponostew to flaccid gistaminovm H_1-retseptoram and shields them from the gistaminom.

Pharmacokinetics

Quickly absorbed and almost completely metabolized in the liver and gut, becoming active metabolite karebastin. A drug with fatty food intake increases and education karebastina by 50% (which, however, does not alter the clinical effect). After receiving a single dose of 10 mg C_max (80-100 ng / ml) is defined by 2.6-4 hours In ejesuternm admission 10 mg equilibrium concentration (160 ng / ml) is achieved in 3-5 days. Linking plasma proteins (including active metabolita) - more than 95%. It permeates through GEB; T_1/2 karebastina - 15-19 hours; 66% displayed product with urine in the form of metabolites. In patients with renal insufficiency T_1/2 karebastina rises to 23-26 hours; With liver failure, until 27 p.m. With increasing age (up to the old) farmakokinetika are not significantly altered.

Farmakodinamika

Does long-term peripheral gistaminove H_1-retseptora without causing antiholinergicakih and sedative effects.

Clinical pharmacology

Once inside expressed antigistaminnoe effect begins in 1 hour, and it lasts for 48 hours After five days of treatment antigistaminnaya activity maintained for a period of 72 hours at the expense of active metabolites. Do not alter the ECG, including Qt-interval in doses up to 80 mg; Does not affect the ability to drive a car and management mechanisms (no sedation).

Indications

Allergic rhinitis and conjunctivitis (seasonal and / or year), chronic idiopathic urticaria.

Pregnancy and lactation

Is not recommended to take because security products in these conditions is not known.

Contraindications

Гиперчувствительност ь.

Side-Effects

Headache, drowsiness, dry mouth, allergization symptoms. Seldom-pain in the abdomen, neuralgia, nausea, fatigue, insomnia, rinita NOSE bleeding, sinusita.

Patient interaction

Compatible with theofillinom indirect antikoagulyantami, zimetidine, diazepam and alcohol. Increases likelihood elongation QT interval in combination with a ketokonazolom and eritromitinom.

Overdosing

Special antidote exists. In the case of an overdose of that scene stomach, monitoring vital functions of the organism, symptomatic treatment.

Precautions

Be wary appoint patients with kidney or liver failure, with the elongation QT interval, gipokaliemiei. There should be combined with eritromitinom, ketokonazolom. It should not be treated with medication for children under the age of 12 (not examined its effectiveness and safety).

Dosing and Administration

Inside, regardless of the meal. Adults with allergicescom rinite appoint 10-20 mg (depending on the appearance of symptoms) once a day. In idiopathic chronic krapiwnice-10 mg once a day.

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