Klarisens

Roman name

Klarisens #

The composition and the form of

5 ml syrup contain loratadina 5 mg, in a dark bottle glass of 100 ml, in a cardboard bundle one bottle complete with enough height of 5 ml and 2.5 mle.1 tablet 10 mg; in a contour acheikova packing 10 pcs.

Characteristics

Colorless or pale yellow liquid with a fruity smell. Exception of bubbles; Tablets white, or nearly white.

Of drugs

Antigistaminnoe, protiwallergicescoe, protivozudnoe, antiekssoudativoe. Blokator peripheral receptors N_1-gistaminovh II generation. Decreases capillary permeability has protivooterne and moderate skin effect.

Pharmacokinetics

Rapidly absorbed, tying with plasma protein to 97%. It permeates through the GEB. C_max achieved through 8-12 hours T_1/2 is 3-20 hours, averaging 8.4 hours The biotransformation formed active metabolite - дескарбоэтоксилората дин. The drug and its metabolites derived from the urine and faeces.

Farmakodinamika

It has sedative action, it is addictive.

Clinical pharmacology

The evolving 30 min after administration and continues until 24 pm In patients with chronic renal insufficiency farmakokinetika does not change. In Puerto defeat liver and the elderly and C_max T_1/2 increasing.

Indications

Allergic rhinitis (seasonal and year-round) and conjunctivitis, severe urticaria, Kwinke swelling, allergic reactions to insect stings, zudaschie Medicine (Contact allergodermatit, atopic dermatos, chronic eczema), psevdoallergicakie reaction.

Pregnancy and lactation

Contraindicated. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, phenylketonuria, pregnancy, breast-feeding.

Side-Effects

On rare occasions, there is the increased fatigue, headache, dizziness, neuralgia, nausea, dry mouth, allergic reactions.

Patient interaction

Erythromycin, ketonzol, zimetidin increase the concentration of drugs in the blood. Klarisens reduced level erythromycin in the blood by 15%.

Overdosing

Symptoms : drowsiness, headache, Tahikardia.lechenie : symptomatic.

Precautions

To apply caution in patients with impaired liver : that the admission of the day (one every two days).

Dosing and Administration

Inside, and food. Adults and children (over 12 years of age or body mass index of more than 30 kg), 10 mg (one tablet or two dimensional spoons syrup to 5 mL) once a day. Children between the ages of 2 to 12 years, 5 mg (1 / 2 tablet or one measuring spoons syrup to 5 mL) once a day.

Storage conditions

syrup : List B. In dry the dark place at a temperature of no higher than 25 ° Ctabl. : List B. In dry the dark place at a temperature below 25 ° C

Shelf life

syrup : 2 g.tabl. : 2 grams.

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