Claritin

Roman name

Scripts

Pharmacokinetics

Rapidly absorbed from the intestine and almost completely metabolized in the liver, with the participation of zitohroma R450ZA4 (CYP3A4) and to a lesser extent, R4502D6 (CYP2D6). C_max loratadina achieved through BLN h, the main active metabolita (декарбоэтоксилората��ина) through 2.5 hours T_1/2 loratadina 8.4 p (3 to 20 hours) декарбоэтоксилоратад ина - 28 p (from 8.8 to 92 h). Admission food has no effect on the achievement of Preparata.vrema C_max increased ~ 1 hour, but the C_max does not change. It passes through GEB; Enters breast milk, which reaches concentrations close to the concentrations in the plasma. Place in the form of metabolites within 24 hours-27% of the urine, within 10 days - 80% of the urine and faeces in equal Kolicestwah.u children 2-12 years after admission to the dose of 10 mg farmakokineticeski profile similar to that in adults.

Farmakodinamika

The effect is manifested through 30 min after administration, reaches its peak during the period between 8 and 12 hours of launch and lasted for more than 24 hours When taken within 28 days of sustainability Otmechaetsa.ne not affect the central nervous system, has no antiholinergicski and sedative action (is awake). The study, which Claritin ® application within 90 days a dose exceeding therapy four times, clinically meaningful elongation QT interval on the ECG were found.

Indications

Allergic rhinitis (seasonal and year-round), symptomatic treatment chihanya, irritated nasal mucous membrane, rinorei, stinging and itching eyes; Chronic urticaria and other skin diseases allergic origin in adults and children over the age of 2 years.

Pregnancy and lactation

When pregnancy is possible if the expected effect of therapy outweighs the potential risk to the fetus (data on the efficacy and safety of available). At the time of treatment should stop breastfeeding.

Contraindications

Intolerance or heightened sensitivity to components, as part of the preparation.

Patient interaction

Ketokonazol, erythromycin, zimetidin increase concentration loratadina and its metabolites in plasma (no clinical significance does not affect ECG). It reinforces the effect of alcohol on the central nervous system.

Precautions

Admission drug should be discontinued 48 hours prior to the skin samples.

Storage conditions

The temperature 2-30 ° C

Shelf life

3 years

The registration

013494/02-2001

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