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Letizen

See also Cetirizine

Roman name

Letizen

The composition and the form of

1 tablet, film coated liner contains cetirizina dichloride 10 mg; in a contour acheikova packing 10 pcs. , in a cardboard unit 1 or 2 packaging.

Characteristics

Round, slightly dvoyakovpuklae pills white in Kołki on the same side.

Of drugs

Antigistaminnoe, противоаллергическое . Yes blocks peripheral gistaminove H_1-retseptora, prevents the effects gistamina (expansion and the capillary permeability necessary for the development of oedema, Urticaria and redness; Initiation of sensitive nerve endings, with everything and pain; Reduction of smooth muscles of the respiratory system and digestive tract). At later stage allergen ingibiruet gistamina allocation and migration Eosinophils.

Pharmacokinetics

Rapidly absorbed from the gastrointestinal (70%), C_max achieved through 1hr Slight metabolised in the liver, displayed with urine largely unaltered.

Farmakodinamika

The expression 20 minutes, reaching a maximum after one hour and continues for 24 hours

Indications

Seasonal and year-round allergic rhinitis, allergic conjunctivitis, chronic urticaria, swelling Kwinke etc. allergic disease.

Pregnancy and lactation

We have to take in the first trimester of pregnancy, in the II-III might be strict grounds. At the time of treatment should stop breastfeeding.

Contraindications

Гиперчувствительност ь components products and gidroxizin.

Side-Effects

From the circulatory system and blood (blood, gemostaz) : Hemolytic anemia, Trombozitopenia.so part of the intestine : nausea, vomiting, pain in the abdomen, diarrhea, constipation, increased appetite, transient increase in transaminaz Pecheni.so the nervous system and sensory organs : drowsiness, a feeling of tiredness, weakness, dizziness, headache, dry mouth.

Patient interaction

Theofillin Cl reduces and increases the plasma concentration of the drug.

Overdosing

Symptoms : agitation, irritability, drowsiness, and the delay urination, tremor, tachycardia, itching, Sapi.lechenie : washing stomach, the appointment of activated carbon laxatives of symptomatic therapy.

Precautions

To apply caution in patients in gemodialise with kidney failure moderate severity, violation of the liver, in old age (to be adjusted dose), and the drivers of vehicles and people skills involve heightened concentration. Not recommended simultaneous application of oppressive central nervous system, and alcohol consumption. It should not be used in children under 6 years of age.

Dosing and Administration

Inside, before or after meals, pancake few liquid adults and children over 12 years in the 10 mg / day, children 6-12 years of age (weighing more than 30 kg), 5 mg twice a day, children 6-12 years of age (weighing less than 30 kg), 5 mg / Sut.na with renal failure (Cl creatinine 11-13 ml / min), hemodialysis (Cl creatinine less than 7 ml / min), or violations of the liver-5 mg / sut.

Storage conditions

tabl.p.p.o. : When temperature is not above 30 ° C

Shelf life

tabl.p.p.o. : 2 grams.

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