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Lomilan

See also Loratadine

Roman name

Lomilan

The composition and the form of

1 tablet contains loratadina 10 mg; in a contour acheikova packing 10 pcs. , in a cardboard unit 1, 2 or 3 upakovki.5 ml suspension for receiving inside-5 mg; in vial 120ml.

Pharmacokinetics

Rapidly absorbed from the digestive tract. It has a high degree of binding to plasma proteins, and a good level of distribution. C_max plasma achieved through 1-1.5 hours after oral receive a single dose of 10 mg. Metabolised in the liver. Many effect first pass through the liver. Treated hydrolysis with the formation of the active metabolita дезкарбоксиэтоксилор атадина. Excreted in the form of metabolites kidneys (40%) and gastrointestinal (41%). T_1/2 for loratadina is 7-11 hours, active metabolita 17-24 hours Penetrates into breast milk and a concentration equivalent to the level of plasma. Pharmacokinetic parameters did not significantly change in elderly patients and patients with renal insufficiency.

Clinical pharmacology

Ingibiruet release gistamina and LTC_4 of fat cells, preventing effect on the smooth muscles and blood vessels. Decreases capillary permeability, inhibits exudation. Warn development and facilitates the allergic reactions. The effect is manifested through 30 minutes after administration and lasts for 24 hours There has to troponostew H_1-retseptoram CNS (no sedative effect), does not exhibit antiholinergicakih and antiserotoninovykh properties. No impact on psychomotor function, mental and intellectual abilities.

Indications

Prophylaxis and treatment of seasonal and chronic allergic rinita, acute and chronic Urticaria, Kwinke pain, allergic conjunctivitis, psevdoallergicakie reaction; Allergic reactions to insect bites; Integrated Management zudath dermatosis.

Pregnancy and lactation

Perhaps if the effect of therapy outweighs the potential risk to the fetus. Is not recommended for women during breastfeeding.

Contraindications

Гиперчувствительност ь any of the components of the preparation.

Side-Effects

Slabovrajenne possible side effects : dry mouth, vomiting. Very seldom can appear : headache, fatigue. Less than 1% of the patients experienced cough, dizziness, nausea, rapid heartbeat, increased appetite.

Patient interaction

Be wary appointed at the same time as the agricultural zitohroma R450 (zimetidin). Alcohol and tranquilizers potenziruut not effect the preparation.

Dosing and Administration

Inside, adults and children over 12 years of age (weight of more than 30 kg) : 10 mg / day, once, that is, Table 1. a day or two dosing spoons suspension (10 ml). Children 2-12 years (weight less than 30 kg) : 5 mg / day, once, that is, dozirovocnaya 1 teaspoon (5 ml), or 1 / 2 table. per day. The maximum daily dose of 40 mg.

Storage conditions

In dry, the dark place at a temperature of no higher than 25 ° C

Shelf life

2

The registration

010317

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