Loratadine

Chemical name

Ethyl ether 4-(8-Хлор-5,6-дигидро-11Н-б ензо-[5,6]циклогепта [ 1,2-b]пиридин-11-илиден)-1- пиперидинкарбоновой acid

Gross

C22-H23-Cl-N2-O2

Characteristics

White or belovaty powder. Nerastvorim in water, it is readily soluble in acetone, alcohol, chloroform.

Indications

Allergic rhinitis (seasonal and year-round), pollinoz, allergic conjunctivitis, chronic idiopathic urticaria, zudaschie Medicine (contact allergodermatita, chronic eczema), angioneuroticeski swelling, bronchial asthma (aid), allergic reactions to insect stings, psevdoallergicakie reaction to gistaminoliberatora.

Restrictions on the use of

Pregnancy.

Pregnancy and lactation

The possible only if the projected benefits to the mother outweighs the potential risk to the fetus and newborn.

Contraindications

Hypersensitivity, breastfeeding, child up to 2 years.

Side-Effects

From the nervous system and sensory organs : headache (12%), clothes (8%), fatigue (4%), 2% or less is a violation of concentration, dizziness, nervousness, anxiety, initiation (children), insomnia, fear, amnesia, depression, giperkinesia, tremor, paresthesia, gipestesia, disfonia, impaired vision, a change slezootdelenia, conjunctivitis, blefarospazm, pain in the eyes and ears, noise in the ears; very rarely Sudorogi.so part of the intestine : dry mouth (3%), 2% and less than Increased appetite, increased body mass index, anorexia, nausea, salivation change, the violation of taste, dental pain, stomatitis, vomiting, gastritis, flatulence, neuralgia, constipation or diarrhoea; very rarely, jaundice, hepatitis, Pecheni.so necrosis of the respiratory system : in the 2% and less-zalojennosti nose, sneeze, dryness in the nose, active bleeding, sinusit, pharyngitis, laringit, cough, krovoharkanye, bronchitis, bronhospazm, pain in the chest, infectious upper respiratory tract Despnoe.so the urogenital system : change the color of urine, painful craving for urinating, dismenorea, menoragia, vaginitis, the weakening Yeah, impotence, it is very rarely Oteki.so the musculoskeletal system : pain in the back, artralgia, mialgia, convulsions stretch Myshc.allergicakie reactions : hyperemia, skin rashes, urticaria, dermatitis, itching, swelling angioneuroticeski; very rarely Anaphylaccia.so the circulatory system : hypertension or gipotenzia, palpitations, tachycardia; very rarely supraventrikuliarnaya Tahiaritmia.prochie : dry hair and skin, thirst, fatigue, malaise, fever, chills, photosensitization, increased sweating, pain in the mammary glands, increased body mass index; very rarely alopecia, an increase in the chest, mnogoformnaya erythema.

Patient interaction

Erythromycin and ketokonazol (inhibitors of P450 CYP3A4), zimetidin (inhibitor P450 CYP3A4 and CYP2D6 R450) increase the concentration of loratadina and its active metabolita in blood. Lowers the level of erythromycin in the plasma (15%). Not potenziruet of alcohol on the central nervous system.

Overdosing

Symptoms : headache, drowsiness, Tahikardia.lechenie : induction vomiting syrup ipekakuana washed stomach, the appointment of activated carbon; Symptomatic and supportive therapy.

Precautions

The treatment that is not less than 1 hour prior to the skin test for allergens.

Literature

J. Slater, D. Zechnich, Haxby D. Second-antihistamines. A comparative review / / Drugs - 1999 .- V. 57-N-1 P. 31-47.

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