Oxatomide

Chemical name

1-[3-[4-(Дифенилметил)-1-п��перазинил]пропил]-1,3-д игидро-2Н-бензимидазо��-2-он

Gross

C27-H30-N4-O

Of drugs

The drugs-antigistaminnoe, membranes, protiwallergicescoe, protivozudnoe, antiekssoudativoe. Competitive blocks gistaminove H_1-retseptora, stabilizes the membrane inhibits degranulatia fat cells and the release of biologically active substances (including gistamina, serotonin). Prevents interaction mediators allergy to the specific receptors, prevents and facilitates the allergic reactions. Decreases capillary permeability, exudation and the development of inflammation, removes cramps smooth muscles of internal organs. Oppressing CNS, blocking m-holinoretseptora (poorly). Once inside quickly and almost completely absorbed. C_max plasma achieved in 2 hours In the blood by 98% associated with plasma proteins. Treated biotransformation in the liver. T_1/2 at 2:00 pm Report unchanged to (0.5%) and in the form of metabolites with faeces (60%).

Indications

Allergic rhinitis, conjunctivitis, dermatitis, urticaria, bronchial asthma (composed of combination therapy), food allergy.

Pregnancy and lactation

Contraindicated. During treatment should stop breastfeeding.

Contraindications

Hypersensitivity, pregnancy, breast-feeding.

Side-Effects

From the nervous system : increased fatigability, sedative effect, dizziness, drowsiness, muscle weakness, convulsions, diskineticalkie neurological reaction (in children). For part of the intestine : dry mouth, increased appetite (using high doses), the phenomenon of diarrhoea, nausea, vomiting, increase transaminaz, гепатит.Аллергически�� reactions : skin rash, swelling angioneuroticeski rarely-anaphylactoidnye reaction.

Patient interaction

Potenziruet deprimiruty effect barbiturates, tranquilizers and sedatives, narcotic analgesics, tranquilizers, alcohol and products containing alcohol.

Overdosing

Symptoms : drowsiness, stalemate, ekstrapiramidnye disorders (diskinesia, wryneck, and distonia gipertonus muscle), less frequently, anxiety, midriaz, Generalized convulsions, aetiology (possible minute). Treatment : washing stomach, the appointment of activated carbon, supporting therapy. In developing symptomatic ekstrapiramidna recommended antiholinergicakie funds.

Precautions

In Hepatic to start therapy with polovinnah doses. Children up to six years of age should be applied with great caution. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention. Patients with bronchial asthma is not recommended to discontinue receiving the drugs, particularly glucocorticoids. During treatment should be deleted alcohol.

Dosing and Administration

Inside. Adults, on 30-60 mg 1-2 times a day; Children weighing 15 to 35 kg, 15 mg, in larger mass of 30 mg once a day (at night).

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