Pipolfen

Roman name

Pipolphen

The composition and the form of

Beans - 1 drageprometazina hydrochloride-25 megawatts blistere 20 pcs. ; In a cardboard box or two 25 Blisterov.rastvor injection-2 mlprometazina hydrochloride-50 megawatts blistere five vials of 2 ml; In a cardboard box two blisters.

Pharmacokinetics

Well drawn from the blood. The effect is manifested through 20 minutes and continued for four to six hours (sometimes more than 12 hours). Linking plasma protein-65%. Intensive metabolised in the liver in the first passage "through the liver. Metabolism is in the liver mainly by S-okislenia. Sulfoxida prometazina and N-demetil-prometazin are major metabolites. T_1/2 - 7-15 hours Write mainly with urine, partly in the form of metabolites.

Indications

Allergic disease (including urticaria, savorotocnaya disease pollinoz, angioneuroticeski swelling, itching of the skin), which represents and posleoperazionny period (as a sedative), the prevention and mild nausea and vomiting associated with infections, and / or aftercare period postoperative pain (in addition to analgesics), the prevention and removal of dizziness and nausea when travelling in transport anaphylacticskie reaction to the admission of PP (as adjuvant therapy after the start of treatment by other means).

Pregnancy and lactation

Contraindicated in pregnancy. At the time of treatment should stop breastfeeding.

Contraindications

Hypersensitivity, coma or a deep oppression CNS, pregnancy, breast-feeding, age and 14 years of age (CT), up to 2 months (injection).

Patient interaction

Do the narcotic analgesics, sedatives and sleeping pills, of narcosis, tricyclic antidepressants and tranquilizers, and antiholinergicakih gipotenziveh of alcohol. When combined with adrenalinom possible perverse arterial gipotenzia and tachycardia (Pipolfen by blocking alfa-adrainoretseptora may distort pressornyi effect contests), with the means that are ekstrapiramidnye symptoms, the likelihood of side effects of the central nervous system.

Precautions

With the utmost care to appoint liver diseases and cardiovascular diseases, with uzkougolna form of glaucoma, stenoziruta ulcer stomach, the neck obstruction bladder and / or exaggerated prostate cancer, patients who are vulnerable to the development convulsing, or receiving Pipolfen with other drugs having similar effects, with ARI, or ARI, children and patients older. There are encouraged to nominate children in a single vomit. With long-term use should be held regularly hematologic studies. Diagnostic test for pregnancy based on the immunological reactions between hCG and Anti-hcg may give lozhnootricationay or lozhnopolojitelny result. It should be borne in mind the likely increase in the level of glucose in patients who Pipolfen, in the performance test in tolerance to glukoze. During treatment are not allowed to drink alcoholic beverages. It should not be used in conjunction with the drivers of vehicles and people skills relate to the high concentration of attention.

Storage conditions

List B. In the dark place at a temperature of 15-25 ° C

Shelf life

5 years

The registration

012682/01-2001

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